Effort Of Different Levels Of Systolic Pressure Before Cardiopulmonary Bypass On Postoperative Cardiac Protonin-â… 

Objective The purpose of this study was to investigate the effort of different levels of systolic pressure before cardiopulmonary bypass and different methods to control systolic pressure on postoperative cTnI in ASDR VSDR.Methods From October 2004 to January 2005 in our cardiac surgical ward 30 patients diagnosed as ASD or VSD were involed in the study. Anaesthetized with isoflurane fentanyl and vecuronium, intubated, and mechanically ventilated. All patients are randomly assigned to 3 groups: â…  group still anaesthetized with isoflurane fentanyl and vecuronium without any other interference ; â…¡ group with propofol 0.5-1mg/kg iv.then 2 mg ? kg^-1 ? h^-1 interfusion; â…¢ group with urapidil 5-10mg iv. CTnI concentrations were measured in serial venous blood samples drawn immediately before operation, 12 and 24 hours after aortic unclamping. Analysis the effort of different levels of systolic pressure and interference on postoperative cTnI concentrations.Results Effort of different levels of systolic pressure before cardiopulmonary bypass on cTnI postoperative is significant, different levels have different effort on postoperative cTnI. B group(SBP 80-100mmHg ) has the slightest release. Different interference does not has the effort.Conclusion The most suitable level of systolic pressure before CPB related to the lest release of cTnI postoperation ranges from 80 to lOOmmHg. Either propofol or urapidil can achieve the level,without increasing the release of cTnI postoperation.