Effects Of Metoprolol Injection On Biochemical Markers Of Cardiac Injury And Cardiac Function In Patients With Acute Coronary Sydrome In Early Stage

Objective To investigate the effects of metoprolol injection on biochemical markers of cardiac injury and cardiac function in patients with acute coronary sydrome(ACS) in early stage.Methodes 72 patients with ACS between January 2004 and December 2004 were randomly divided into two groups on a basic medical therapy: metoprolol injection group and control group:35 patients in metoprolol injection group were injected metoprolol 15mg in early stage and given metoprolol tablet after injecting metoprolol. 37 patients in control group were only given metoprolol tablet. A consecutive series of levels of cardiac troponin I(cTnI) and creatine kinase-MB(CK-MB) were detected in 72 patients. The data of ventricular function were measured by echocardiography at 2 weeks and 4 weeks after admission.Results In metoprolol injection group,the levels of biochemical markers were significantly decreased , as reflected by the decreased cTnI at 12 hours and 24 hours and the decreased CK-MB at 12 hours compared with those in control group(P<0.05). There were no significant difference between the two groups on left ventricular ejection fraction(LVEF) and left ventricular end-distolic volume(LVEDV) after 2 weeks and 4 weeks. In metoprolol injection group, left ventricular end-systolic volume(LVESV) was significantly decreased at 4-week compared with that in control group(P<0.05). The levels of cTnI and CK-MB were negatively correlated with LVEF (r = - 0.316, P<0.01; r = - 0.251, P< 0.05) at 12 hours.Conclusion On a basic medical therapy, metoprolol injection on ACS in early stage can decrease the levels of biochemical markers. The levels of cTnI and CK-MB were negatively correlated with LVEF.