Study On Pharamaceutics Of Biejia And Shanzha Granule

Following that the living environment was being deteriorated day and day and the living level was being continuously raised,fatty liver and symptom of fibred liver that menace the health of human beings gradually become the common diseases. These diseases have some complicated characteristics. For example, the course of diseases are very long and they are difficult to cure. So to look for the good medicine to prevent and treat these diseases is a research focus in our country and abroad. At present there are some drugs for curing liver diseases, but basically they have limits at curing ills. However, in our country medical science treasure-house we will explore a safe,efficacious and convenient medicine to prevent and treat our livers.From the name of the medicine we can know the Shanzha Biejia granule are mainly composed of Shanzha and Biejia. According to the theories of traditional Chinese medicine, Biejia is saltish and slightly cold has the efficiency of soothing the liver to regulate the flow of vital energy, supports the body fluid and energies. Shanzha can eliminate the stasis of blood and indigestions. Both of them may ameliorate and protect the function of liver by through clinical practice.Through doing textual research, single and complex folk prescriptions of Shanzha and Biejia has been used un treating fatty liver and symptom of fibred liver, especially for the compatibility of these medicine which improve the therapeutic activities and has efficiency soothing the liver to regulate the flow of vital energy, strengthen the spleen by oozing wet firmly of invigorating blood cieculation etc. The medicines in the prescription are good for curing liver complaints.And yet this text brings forth new ideas that according to the theories of traditional Chinese medicine, we adopt the contemporary techenology- micropowers. Micro-powers technology thatcan raise medicinal solubility and organisims utilization-ratio. By means of this craft, the diameter of medicine material can be shattered to 0.1-75μm. During pharmacological experiments and screening of preparation technology, the main components of Hugan granule have determined, and quantitative analysis has confirmed, The contents of Ursolic acid the examination preparation was ascertained and the preparation craft, quality standard and preliminary stability of the granule were systematically studied respectively too.In order to improve further therapeutic effect of the preparation and be absorbed and preserved the efficaciousand activated component,Biejia was shattered by airflow into micro-powders. We selected total quantity of dry ointment and The contents of Ursolic acid as marker, utilizing L9(34) orthogonal test to optimize the best process of alcohol-extraction and determined jt as following:adding 10 time 85% EtOH, extracting 3 times and boiling 2h each time. The establishment of the quality standard of Shanzha are identified by TLC. TLC spot is fairly clear ,and the bland test shewed no interfereance , special attribute is strong . Ursolic acid as determination targest, establish the content method by HPLC , Average recovery rate was 99. 53% . it is reliable to show the method accurately . Finally carry on preliminary stability to study to the Hugan granule , accelerated stability (40℃ ,RH75%) investigate 3 month . Hugan granule was studied for 3 months under room temperature. The result showed it kept stable during the time . These research above apply reliable base for the preparing and clinic effect.