Chaiqin Milk Granule Preparation Process, Quality Standards, Stability, And Initial Intestinal Absorption

Hyptroplasia of mamma rygland is a common breast disease in women. operation and hormone are applied in west medicine, but these methods can not accepted by most of patients due to its frequent by-effects and easily got it again after operation. Chinese medicine have its own theory and methods for the appearance and origin of this disease. This prescription derived from experience summarized by Chinese medicine doctor, and granule agent was made through modern technical method to cure a kind of hyptroplasia of mamma rygland in order to develop clinical effect and adapt to the need of market。 1 Documents summaries Standpoint about hyptroplasia of mamma rygland in Chinese medicine, the reason and mechanism,type and cure rule, Standpoint about hyptroplasia of mamma rygland in west medicine and cure rule. clinical drugs in Chinese and west medicine. 2 Experiments 2.1 The research of pharmaceutical including pharmaceutical technology, quality standard and absorption outside body. Pharmaceutical technology: Granule was selected by virtue of theories of pharmaceutical technology design and characteristics of fourteen Chinese medicine. The optimum technology as follows: huangqin(Scutellaria baicalensis Georgi)was extracted and refined solely. oil was extracted from Chaihu(Bupleurum chinense DC.),chenpi(Citrus reticulata Blanco),foshou(Citrus medica L.var.sarcodactylis Swingle)and chuanjiao(Zantho-xylum bungeanum Maxim.) and wrapped by β-CD, Orthogonal test was employed to determine the optimal condition. Pharmaceutical technology was determined after extraction. Quality standard research: The component was evaluated by TLC ,The content of baicalin and paeoniflorin was determined through HPLC method. Absorption research outside body:Determined and estimated octanol-water partition coefficients ,everted gut sac was applied to research absorption condition of small intestine through testing decrease of content of baicalin outside of small intestine. Results indicated that the absorption of baicalin in small intestine pH3.5 is good. The best extraction and pharmaceutical technology and quality standard was determined, and absorption research indicates that absorption of baicalin is good in small intestine. 2.2 The relationship between package materials and drugs The relationship of drugs and package materials was researched by testing increase or decrease of content of effective component, fluorescence substance, volatile and heavy metal . Accelerated test was employed in this research .