Effects Of Endurance Training On The Activities Of NFκB In Dorsal Root Ganglia Of Diabetic Rats Induced By STZ

Background and objective:The clinical epidemiologic investigation showed that more than 8% of the fresh diagnosed diabetic patients had been in combination with symptoms of diabetic neuropathy, especially symptoms of diabetic peripheral neuropathy (DPN). Animal and in vitro experiments over the last thirty years have implicated that there were several major pathways of glucose metabolism in the development of diabetic neuropathy, in which oxidative stress was focused. NFkB is a kind of oxidative stress sensitive transcription factor, the activation of which may function as a pivotal regulator of stress response. The primary sensory neurons, also known as dorsal root ganglion (DRG) neurons, are uniquely vulnerable by hyperglycemia in all sorts of cells to result in DPN. Previous studies focused mostly on the impaired exercise capacity in DPN as validity of exercise training for DPN is disputed. However, It was as yet unclear that whether exercises can prevent and/or improve diabetic peripheral neuropathy or not. Therefore, in this study we explore the effects of endurance training on the activation of NFkB in DRG of diabetic rats induced by streptozotocin (STZ). Method:Forty-four male Sprague-Dawley rats were in for this experiment, thirty-four rats of which were modeled successfully for diabetes by STZ injection. The diabetic rats were randomly divided into six groups:...