Effects Of Endurance Training With Different Intensity On Blood Glucose And GLUT4 Gene Expression In Skeletal Muscle Of Diabetic Rats

ObjectiveWe explore the effects of endurance training with different intensity on GLUT4 gene expression in skeletal muscle of diabetic rats. MethodsMale Sprague-Dawley rats were used to this experiment. Thirty-six of rats were subjected to establish diabetic model by injection of streptozotocin. The diabetic rats were divided randomly into six groups: low-intensity training (EL, n=6), high-intensity training (EH, n=6), low-intensity training with insulin injection (LI, n=6), high-intensity training with insulin injection (HI, n=6), control without insulin injection and training (DM, n=6) and control with insulin injection and no training (DI, n=6). Six non-diabetic rats were used as to normal control group without training (CN, n=6). Animals with endurance training were forced to running on motorized treadmill for 8 weeks. The rats with insulin were subcutaneously injected for 8 weeks. Expressions of GLUT4 gene in skeletal muscle were measured by RT-PCR. Result1. The levels of quiet blood glucose in rats with LI decreased...