An Experimental Study About Contrast Medium Injection Rate And Dose In Cerebral CT Perfusion Imaging

Objective To investigate the suitable injection rate and dose in multislice CT perfusion imaging.Methods Randomized block design was adopted in this study. The treatment factor-contrast medium injection rate was classified into 3, 4, 5, 6 and 8(ml/s); the subjects were divided into 5 blocks grouped by contrast medium injection dose: 0.5, 0.75, 1.0, 1.25 and 1.5(ml/kg) 25 Beagles were randomly enrolled to undergo cerebral CT perfusion imaging. After post processing, time to peak (TIP) and rise value (RV) were measured in superior sagital venous.Results Injection rate had a statistical significant effect on TIP of superior sagital venous. There was no significant difference among group 5, 6 and 8ml/s. Compared with 8ml/s, TTP of superior sagital venous was prolonged when injection rate 3,4 ml/s were adopted. Injection dose had a statistical significant effect on RV of superior sagital venous. There was no significant difference among group 1,1.25 and 1.5ml/kg. Compared with 1..5ml/kg, RV of superior sagital venous was prolonged when injection dose 0.5,0.75 ml/kg were adopted.Conclusion The quality of cerebral CT perfiision imaging was well enough even injection rate as low as 5 ml/s or injection dose as few as 1 ml/kg.