The Effect Of Pituitrin On Rabbits With Endotoxin Shock

Objective: As vasoconstrictor, catecholamine is the common medicine used in treatment of infective shock. Pituitrin is also have prominent effect on contracting blood vessel. The present study was to discuss the effect of pituitrin on rabbits with endotoxin shock by comparing with noradrenalin.Methods: Thirty six New Zealand rabbit models of endotoxin shock, injected colibacillus coli toxoid(LPS,0111B4), 300 μg/Kg, were randomly divided into three groups. Every group had 12 rabbits. Group A was not resuscitated by any medicine except injected equal normal saline as many as Group B and Group C. Group B was resuscitated by pituitrin and Group C was resuscitated by noradrenalin. All groups were monitored and noted heart rate, breath rate and blood pressure. Blood gas and NO, CKmB, ALT, AST, BUN, Cr in blood were mensurated at the time of before shock, shock 0, 30, 60, 120, 180, 240min. After the experiment was finished, autopsy was performed and heart, lung, liver, kidney, intestine samples were taken to pathologic study.Results: At shock 60, 120, 180, 240min, the mean arterial blood pressure (MAP) of Group B and Group C has no significantly difficent (P>0.05). The NO concentration of Group B was markedly decreased at shock 120, 180, 240min, what was significantly difficent with Group A and Group B (P<0.05). It prompted that pituitrin could inhibit the formation of NO. At the same time, the concentration of CKmB, Cr of Group B was significently difficent with Group C (P<0.05), what prompted that pituitrin has less impact on cardiac muscle and kidney than noradrenalin.Conclusions: Except damatic action of cantracting blood vessel, pituitrin can inhibite NO formation, what was the mechanism of antishock. It has less influence on the function of kidney and myocardial...