An Association Study Of 5-HTT Gene Polymorphism With Depression And Ssri Clinical Treatment Response

The pathogenesis of depression is complexed. Abnormalities in function of the central serotonergic system are important facts in etiology of depression. So the genes that code for proteins involved in regulation of serotonin synthesis, release, uptake and metabolism, are major candidate genes in association studies of depression. The 5-hydroxytrypamine ransporter(5-HTT) is the major determinant of serotonin reuptake following release at synapses and it is a target for Selective serotonin reuptake inhibitors(SSRIs)antidepressant treatments. Scientists have found that the serotonin transporter-linked polymorpic region (5-HTTLPR) polymorphism of human 5-HTT gene can regulate the transcriptional activity of the gene, and may be one of good candidate genes of depression. And it's also the research focus whether 5-HTTLPR could partly account for differences in SSRIs antidepressant response.Part I An association study of 5-HTT gene polymorphism and Depression Objectve To explore the association between the depression and 5-HTTLPR of the han Chinese and provide theoreitic evidences for clarifying the etiology of depression.Methods With polymerase chain reaction-restriction fraction length polymorphism technique, 5-HTTLPR were determined in 80 patients with depression and 65 control subjects; Results 1. the two alleles of 375bp (S) and...