Difference Of Intercellular Adhesion Molecular CD11b Between Bare Stent And Drug-eluting Stent

Background: since PTCA were widely used in clinical, it became one important and effect method curing CVD. Stenting-using expand the compliance of PTCA, increase security and successes of PTCA, decrease acute occlusion and restenosis. But restenosis afer stenting still high(20%-30%) . drug-eluting stent can decrease the restenosis. It can be confirmed that cause of restenosis was proliferation and transferation of SMC, and inflammation response was important in this process. White blood cell was activated in it and have a role . the activated white blood cell can stimulate adhesion and congregation of blood platelet. It also can adhere to the wall of blood vessl, release activated cytokinese, aggravate the injury of endothelium. How the drug-eluting stent affect the inflammation response were pooly studied. Objective: compare the difference of intercellular adhesion molecular CD11b between bare stent and drug –eluting stent. Methods: the patient who underwent stenting divided into two groups, bare stent group and drug-eluting stent group. All the patient were taken blood from peripheral at different time point. Expression of CD11b was measured by FCM. Result: (1) there was no difference in pre-stenting. And no difference in post-stenting at 24hours , 72 hours. (2)There was difference at 48 hours after stenting(p<0.01). (3) there was difference between pre-stenting and post-stenting at different times.(4) the climax level of CD11b was obtained at 48 hours after stenting. Conclusion: (1)stenting can stimulate white blood cell, espically granulocyte and monocyte, and increase the level of CD11b.(2)Txaol can inhibit the activity of white blood cell, so decrease the level of CD11b.(3) the inflammation of post-stenting was evident at 48 hours.