| Coronary heart disease has become one of the major diseases which affect the human health. The mortality and morbidity go up significantly in China and worldwide. Recently, Percutaneous transluminal coronary angioplasty (PTCA) was one of the most effective and broadly used in revascularization. However, complications such as acute occlusion adversely affect the long term results of PTCA. Intracoronary stem implantation may prevent the acute occlusion, but accompanied with restenosis rate of 20-25%. The inflammation may play an important role in the development of RS. Both local and systemic inflammation were initiated from the reperfusion. the activation of platelets, leukocytes, adhesion molecules and cytokines, which may develop the microvascular thrombosis. Recent studies demonstrated that magnetic field may be beneficial for anti-inflammation, such as speeding up the absorption of inflammative effusion, the transformation of histamine. Therefore, we hypothesis that the magnetic field may affect the inflammative factors related with RS. This study is to compare the serum level of inflammatory factors, Mac-l(CDl lb/CD18) and CD14, in the coronary circulation after the implantation of conventional stents and magnetic stents, so as to investigate the inhibition of local magnetic field on the level of inflammatory factors, which may explain the mechanism of the prevention effect of magnetic field on RS. Method:The study included 43 consecutive patients undergoing selective angioplasty andinstant stent implantation from April. 2000 to January, 2002. 35 of them were male,while 8 were female. They were assigned into magnetic stent (MS) group andnon-magnetic stent (NMS) group. Each group was divided into subgroups ofpre-dilatation stenting and direct stenting. Blood was taken from the coronary sinus atseries time points before, immediately after, 30 minutes, 1 hour, 3 hour, 6 hour afterthe procedure. The expression of CDllb/CD18 and CD14 were measured by directimmunofiuorescent method with flow cytometry.Results:1. The change of CD lib/CD 18 expression in coronary sinus pre and postPTCA&ICSP.There was no significant difference of CD1 lb/CD18 between The expression of was not significant different in either non-magnetic stent or magnetic stent group pre and immediately post PTCA/ICSP, while it significantly increased 30 minutes and 60 minutes post procedure(P<0.05). The expression level of CDllb/CD18 had no difference between MS group and NMS group, but increased significantly in IDS subgroup compared with that of DS subgroup.At either 3 hour or 6 hour post procedure, the expression level of CD lib/CD 18 increased significantly in either NMS group or IDS group compared with that in either MS group ( P<0.05)or DS group (PO.01) at any previous time points (PO.01).2.The change of the expression level of CD14 on the surface of monocyte in coronary sinus pre and post PTCA/ICSP.There was no significant difference of the expression level of CD 14 pre and immediately post PTCA/ICSP. On the other hand, the expression level of CD14 were higher at 3h and 6h post PTCA/ICSP than that at previous time points(P<0.01). Theexpression level of CD 14 in NMS group was much higher than that of MS (P<0.05 ) . There was no significant difference among subgroups (P>0.05) . Conclusion:1. The expression of Mac-1 (CDlib/CD 18) on the surface of neutraleucocyte were elevated continuously post PTCA&ICSP. It symbolized that the procedure of both PTCA and ICSP may activate the neutraleucocytes.2. The expression of CD14 on monocytes elevated slowly post PTCA and ICSP. It may suggest that the initiation of local chronic inflammation should have started within hours post PTCA/ICSP.3. The expression level of both Mac-1 and CD14 was significantly decreased in the group implanted with magnetic stent. It may suggest that magnetic stents could reduce the local inflammation.4. There was significant difference of the expression of Mac-1 on neutrophil su...
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