Study On The Transdermal Therapeutic System For Nitrendipine And The Research Of Medicament Dissolubility Improvement With Surfactants

This paper consists of two parts. One is the study on the percutaneous absorption of nitrendipine. In this part, nitrendipine transdermal absorptable was made. The promotion of nitrendipine on the permeability was studied and the percutaneous mechanism of nitrendipine suspension was researched. In the other part, the improvement of dissolubility of sulfadiazine and aspirin enteric-coated tablet is studied with surfactant as modifier.This paper consists of five chapters.Chapter one: The recent progress of transdermal delivery system has been reviewed with the relative references of 62.Chapter two: The permeability percutaneous absorption of nitrendipine cream was studied using modified Franz diffusion cell and isolated rat skin as permeation barrier. The penetration enhancer could obviously enhance the percutaneous permeation of nitrendipine cream and the accumulative permeation quantity of nitrendipine cream containing oleic acid increased remarkably compared with that of nitrendipine cream without enhancer.Chapter three: The permeability of nitrendipine through rat skin in vitro was examined using the self-made Franz diffusion cell. Accumulative permeation quantity (Q) and steady percutaneous speed (k1) were determined and the percutaneous mechanism of nitrendipine suspension was studied at the same time.Chapter four: To improve the dissolution of sulfadiazine (SD), surfactant such as Tween-80 and OP-10 with different concentration was added. To insure diffluence percent above 70% before 60min, the proportion of Tween-80 and OP-10 should be above 1.162% and 1.059%, respectively.Chapter five: The influence of different concentration of glyceryl monostearate and tween-80 on asprin was studied and the optimum percent in the tablet was determined.