Polyethylene Glycol In The Matrix Of Umbilical Points Transdermal Drug Delivery System Suitable For Research

Therapy is the umbilical cord in the hole by (the navel) administration or in the umbilical give some physical stimulation (moxibustion, and hot, etc.), for the treatment of human diseases. External treatment is one of Chinese medicine can also be classified as modern medicine Transdermal therapeatic syste (TTS) category.There is a long standing history in the theory of the chinese, therapy on the umbilical have been recorded in Internal Classic of Huang Di which two thousand years ago, ancient medical books from theory to clinical application and constantly enrich and develop. Umbilical therapy clinical application of modern medicine broader, involving various body systems, and have achieved a unique medical effects. However, the current point in the umbilical in the development of transdermal drug delivery formulations are more backward, modern preparation techniques in the hole in the navel transdermal drug delivery of appropriate research, the umbilical in the clinical application of acupoint transdermal drug delivery and development of far-reaching practical significance.This issue is a matrix of polyethylene glycol such as umbilical Point to transdermal drug delivery system suitable for research. Through the large number of documents for the inspection and sorting, according to the special structure of umbilical and physiological characteristics that determine the solid paste paste in the hole as the navel transdermal drug delivery formulations. Had umbilical Point to transdermal drug delivery technology of preparation of the molding; respectively peony extract, Corydalis Yan Shao extract and extract compound as the main drug of polyethylene glycol and poloxamer preparations for the matrix the maximum drug loading were investigated. Umbilical prepared into suitable transdermal drug delivery agents in the hole, using mouse umbilical skin, through Franz diffusion cell in vitro penetration test studies; and was carried to the traditional form of powder for the transdermal delivery system of comparative experiments; pharmacokinetics experiment, using healthy adults, Shao Yan paste sticking plasters, comparative study of human umbilical and medial arm skin permeability of drugs; through the pharmacodynamic and toxicological experimental study to verify the umbilical Point to paste Paste transdermal drug delivery and the toxicity. This topic also on human umbilical temperature, surface temperature and the physical morphology of umbilical determination point for the umbilical in the design of transdermal drug delivery agents to provide a reference."Polyethylene glycol matrix umbilical Point to transdermal drug delivery system suitable for research" that conforms to umbilical Point to transdermal drug delivery formulations and methods of quality evaluation system. Explained the matrix, to promote transdermal absorbent and the relationship between drugs for transdermal drug delivery umbilical Point to paste paste screening and evaluation process provides a method; through the toxicology, pharmacodynamics, pharmacokinetics and other experiments, from another Umbilical points and proved to transdermal drug delivery in the paste Paste the safety, efficacy, stability and controllability. On human umbilical temperature, surface temperature and the physical morphology of umbilical determination point for the umbilical in the design of transdermal drug delivery agents to provide reference data. In short, the subject of modern preparation techniques through experimental studies, umbilical Point to provide a transdermal drug delivery formulations scientific support.