| Objective: To study the terminating therapeutical effect of Xiaoyao nose dribbling liquid on migraine, and explore its action mechanism. Methods: Clinical study was based on the clinical study instructional doctrine of the traditional Chinese medical new drug curing migraine. We selected 126 patients who were randomly divided into control group and treatment group, and observed the headache symptom, following symptoms, hemorheology and TCD; Wistar rats were applicated in the experimental study, and created the migraine model by subcutantaneous injection of nitroglycerin. We observed the behavior symptom and c-fos gene expression in brain stem and hypothalamus of them. Results: The clinical total efficiency is 93.33% in treatment group, and 18.33% in control group, there is significant difference between them (P<0.01). The headache and following symptoms of the patients in treatment group were remarkably improved in short time, and their hemorheology and TCD were taken an obvious turn as well. The experimental studies have proved that the Xiaoyao nose dribbling liquid can quickly terminate migraine attack and significantly anti-express c-fos in brain stem and hypothalamus. Conclusions: Xiaoyao nose dribbling liquid has extremely precisely therapeutical effect, moreover, it can fast takes effect and has certain action mechanisms. The study achievements provide new thoughtways and methods.
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