Angelica Nose With The Experimental Study Of The Gel

Object :This task against one of the most common illnesses of migraine, Baizhi selection of traditional Chinese medicine, the use of modern preparation techniques, its extraction, purification, and to make them available nasal gel. Through this study,Baizhi for the development of new drug-delivery system has laid a solid foundation and rich Sichuan authentic ingredients Baizhi use.Methods :Total coumarin content and yield of dry extract indicators inspected Baizhi extraction methods and extraction; single factor inspected the macroporous resin purification Baizhi total coumarin process; From the character, identification, inspection and determination etc. Baizhi extract of quality control; Single combination of factors orthogonal design method to gel stability and in vitro release of the screening matrix and additives, determine the final gel formulations recipe and preparation method; From the characters, identification, examination and determination of the aspects of preparations for the Quality Standard; Through antipyretic, analgesic and anti-inflammatory agents experimental study of the efficacy, With the toad palate model to evaluate Baizhi nasal gel right Clearance effect of the inspection agents toxicity.Result : Baizhi Extraction Process to join Baizhi powder impregnation modest 70% ethanol for 12 hours, Percolation rate of 0.5ml/min and six times the volume of liquid Percolation; Macroporous resin purification technology Baizhi total of coumarin from Baizhi Percolation liquid vacuum to remove ethanol alcohol flavor, add water to the volume of 0.05g health medicine per 1.0 ml , to 1.0ml/min speed dynamic adsorption on the Resin column , 30 min adsorption reservations, seven times the cylinder with water, eight times the 30% ethanol has washing, washing up liquid, then eight times in 80% ethanol eluting rate 1.0ml/min, eluate collection; Baizhi extraction is with oil,gas fragrant powder , it can identify isoimperatorin and isoimperatorin spots , moisture content must not exceed 5.0%, the total ash content not exceeding 4.0%, acid insoluble ash content not exceeding 1.5%, Alcohol insoluble shall not exceed 5.0%, extract content to content isoimperatorin or may not be less than 8.2%,to isoimperatorin total of no less than 4.59%; Baizhi gel method for the system to take Carbomer glycerol wetting ground, swelling appropriate distilled water for 24 hours as a gel matrix standby; Baizhi to extract (using propylene glycol solution), sodium sulfite, peppermint alcohol, Azone, Bromogeramine. EDTA were added gel matrix, flour later transferred Triethanolamine pH7.0 near Distilled water to increase prescription volume, grinding uniform; Baizhi Gel for yellow, uniform and delicate, translucent gel-like; Gel pH of 6.0±0.3 content isoimperatorin dollars less than 2.78mg/g; Baizhi gel has strong antipyretic, analgesic and anti-inflammatory effect, ciliotoxicity smaller.Conclusion :The use of modern technology to Angelica dahurica preparations made nasal gel is feasible. Preliminary efficacy also showed that the preparation of the potential value, it indicates that the preparations necessary to conduct further research and development.