The Correation Analysis Of C-reactive Protein And Interleukin-6 With Type 2 Diabetic Nephropathy

Diabetes and its chronic complicating diseases have become the main danger disease. Diabetic nephropathy (DN) is a common and serious microvascular complication of diabetic mellius and becomes one of disease, which can cause death. The exact mechanism of DN is not clear.In recent years, there are more and more evidences which indicate C-reactive protein and Interleukin -6 is close association with DM and DN. Objective: To investigate the levels of serum CRPand IL-6 in different stages of DN and their implication. Methods: This study included 30 healthy subjects and 80 patients with type2 diabetes mellitus, diabetic patients were further divided into three subgroups according to their urinary albumin excretion rate (UAER): 20 Patients with normal UAER, 34 Patients with microalbuminuria and 26 Patients with clinical proteinuria. CRP, IL-6, UAER, fasting blood glucose (FBG), hemoglobinAlc (HbA1c), blood aura nitrogen (BUN), blood cretonne (Cr), body mass index (BMI), cholesterol, blood Pressure were measured. All these data were expressed as mean ± SE, statistical comparisons were done using independent test or one-way analysis were applied when appropriate. All the statistical analysis was dealt with sPss10.0 software. Results: 1: The serum level of 11-6 and CRP in Patients of A group, B group and C group were significantly higher than those in healthy controls (P<0.01 or P<0.05); 2: Serum...