Correlation Between Eotaxin Expression And Eosinophils Activation In Nose Polyps

Objective: to study the relationship between expression of eotaxin and eosinophils(EOS) activating in nose polyps(NP) ; study the essential function of corticosteroid in them and as one of main mark of activated eosinophils, eosinophil cationic protein (ECP) may be utilized in clinical diagnosis, adiminister drugs, evaluation of curative effect et al.Methods: The specimens of twenty nasal polyps, twenty dexamethasone and twenty control subjects with similar sex and age were studied :set up three groups (nose polps, dexamethasone, normal control). Twenty patients with NP were treated by DXM(20mg, qd×5) as dexamethasone group. Total count and percentage of eosinophil in periphearl blood(PB) were measured; the level of ECP in serum were detected by Pharmacia CAP system;and the pathologic samples of nose polps tissue were stained with HE; the expression of Eotaxin were observed by IHC(immunohistochemistry). The results were analysized by SPSS and linear correlation. Results:compared with the dexamethasone and normal contral groups, eosinophil numbers of PB (54. 40±6. 37× 10~7/L) ;ECP level (16. 47 ± 5.38 μg/L) and Eotaxin cells (50.85 ± 32.22) were expressed at high levels (p<0. 05) in nose polyp tissue, and the activated eosinophils increased.The expression of Eotaxin positively correlated with the level of ECP(r=0. 647) ;Glucocorticoids prominently inhibited eosinophil numbers of PB (16. 01 ±2. 14×10~7/L ; ECP level (6.26 ± 3. 13μg/L) and the expression of Eotaxin cells (15.21 ± 11.32) (p<0.05) ; eosinophil numbers of PB...