The Correlative Study Of Relationship Between Brain-stem Auditory Evoked Potential And Platelet-activating Factor For High-risk Infants

Objective High risk factors on hearing in infants is a relatively common and serious problem.lt maybe accompanied by cytokin such as platelet-activating factor(PAF). The present study aimed to investigate the incidence and morbidity of hearing impairment and the effect of high risk factors and platelet-activating factor on hearing loss in neonates with high risk factors in neonatal intensive care unit (NICU). Methods 204 infants 408 ears were evaluated hearing loss by brain-stem auditory evoked potentials (BAEP) in NICU during the period from 2001 to 2003. Infants who failed the first test were followed up ,and accepted the second test in 3 months and CD62p was quantified with the flow cytometry.Results (1) 125 ears failed the initial test, 16 ears failed the second test, the inspection rate of hearing impairment was 33.1%, 3.9%, respectively. In this study, high risk factors of hearing loss included severe asphyxia, hyperbilirubinemia and premature. (2) The inspection rate of the initial and second tests were 35.2% and 4.4% in preterm infant, respectively. There were a consistent reduction in the occurrence of hearing impairment by increasing birth weight and gestational age. The presence of coexisting severe asphyxia, hyperbilirubinemia, meningitis, exposure to dopamine increased the risk of hearing impairment. (3) In infants with asphyxia, the inspection rate of the initial test was 54.8%, and it was significantly increased with degree of asphyxia (p<0.05). The inspection rate of the second test was 7.1%, that of the HIE group was 16.7%. The damage on hearing pathway of asphyxia combinedwith HIE was significantly more severe than that of without HIE. (4) In the group of hyperbilirubinemia the inspection rate of the initial and second test was 33.3%, 4.4%. 3 of ears cases showed abnormal in auditory function at 3 month. 2 of ears were mild hearing loss and 1 was moderate hearing loss. The occurrence of failing the initial test increased with the level of serum bilirubinemia. The inspection rate increased with of coexisting acid toxicosis and infection. (5) CD62p expressioned in neonates who failed the initial BAEP test were significant higher than that who passd. Conclusion Low birth weight and gestational age, asphyxia and hyperbilirubinemia were high risk factors of hearing loss in infants. The expression of PAF CD62p was increased in infants who failed the initial BAEP test. It implied that using of anti-PAF maybe an effective method of treatment hearing loss.