| Acute coronary syndromes is one of the serious cardiovascular disease that is threating people health seriously. The pathophysiological mechanism responsible for ACS including unstable angina (UA), acute non-Q wave myocardial infarction (NQMI) and acute Q wave myocardial infarction (QMI) are believed to the injure of endothelial function that continued to coronary plaque disruption , subsequent platelet aggression and vessel thrombosis. Endothelial injury can cause smooth muscle cells proliferation and vascular lesion in coronary atherosclerosis, so endothelial cells play an important role in the pathogenesis of coronary atherosclerosis. Hepatocyte growth factor (HGF), initially regard as a growth factor specific to hepatocytes, is now established to be a multipotent growth factor whose receptor c-met is not only expressed in normal tissue but also in different cell types, including cardiac myocytes, endothelial cells, and hematopoietic cells. The general activities of HGF were found to be mitogenesis, motogenesis, morphogenesis. Upregulation of HGF and c-met mRNA can be observed after endothelial injury, which can promote the survival of endothelial function. HGF isa potent angiogenesis factor in myocardial ischemia. Although HGF is stronger than vascular endothelia growth factor (VEGF) and fibroblast growth factor in mitogenesis, it does not affect smooth muscle cell proliferation. Patients with ACS can develop serious cardiac events and sudden cardiac death. It is an important to find some biological markers to predict the diagnosis and prognosis of ACS in clinical condition; The levels of HGF, VGEF and TNF- α are significantly higher in patients with ACS than that in control group, which in turn contribute to the regeneration of endothelial cells and the angiogenesis. The relationship between HGF and CHD were attached much attention recently in cardiovascular research. But there is no report about the correlation of HGF and ACS in our country. In order to offer theoretical basis, the research focus on the correlation of HGF and ACS.Methods: (1) 63 patients with coronary heart disease (CHD) were divided intothree groups according to the degree of coronary artery stenosis : mild group 18 subjects ; moderate group 22 subjects ; serious group 23 subjects .The levels of serum HGF, VEGF, TNF-α were detected with enzyme linked immune absorption assay (ELISA), and were compared with those 20 control subjects . The groups of CHD were divided into four groups according to angina pectoris grade: grade I 13 subjects, grade II 15 subjects, grade III 16 subjects, grade IV 19 subjects, and they were compared to the levels of HGF, VEGF and TNF- α . (2) 56 patients with UAP were divided into two groups by cardiac events including acute myocardial infarction, sudden cardiac death and refractory angina pectoris: cardiac event group 20 subjects, no-cardiac event group 36 subjects and control group. The levels of HGF and VEGF were measured.Results: (1) Serum HGF levels were significantly higher in the serious group, moderate group and mild group than in the control group (P<0.01). Serum VEGF levels were significantly higher in the serious group and moderate group than in the mild group and control group (P<0.01); Serum TNF- α levels were significantly higher in the serious group and moderate group than in the mild group and control group(P<0.01). There was positive correlation between angina pectoris and the levels of HGF ,VEGF and TNF- a ; Correlation coefficients are n =0.864 (P<0.01), r2 =0.682 (P<0.01), r3 =0.403 ( P<0.01), respectively. (2) Serum HGF were significantly higher in UAP group (1414.14 + 631.89)pg/ml (P <0.01) ; Serum VEGF levels were significantly higher in UAP group(94.57± 26.18) pg/ml than control group (56.59±14.66) pg/ml (P <0.01) ; Among patients with UAP, the levels of HGF were significantly higher in cardiac event group (1691.54±574.66) pg/ml than no-cardiac events group (1232.25±616.43)pg/ml, (P <0.01) . The levels of VEGF were significantly higher in cardiac event group (105.99±24.24) pg/ml than no-cardiac events group(88.22±25.34)pg/ml, (P <0.01) .No significance difference was found in serum CK and CK-MB levels in all the groups.Conclusion: (D Endothelial cells play an important role in the rise anddevelopment of coronary heart disease. HGF, as a potent mitogenesis, can protect heart function.? HGF VEGF and TNF-a in patients with CHD were significantly correlated with coronary stenosis and angina pectoris grade. The correlation of HGF was better than the correlation of VEGF and TNF- a ,so HGF may be as a new marker for surveillance on ACS. (3) The levels of HGF, VEGF were significantly higher in cardiac event group than no-cardiac event group; these indicate that there are correlation among the levels of HGF, VEGF and unstable angina.
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