| Objective: To investigate the effect of high-frequency stimulation of SNRanterior on the behavior scale and EEG manifestation in the penicillin-induced and fully developed epilepsy .Methods: 48 male adult Wistar rats were randomly divided into control group and two experimental groops, i.e. bilateral SNR stimulation group and ipsilateral SNR stimulation group. Each group had 16 male Wistar rats.Depth electrodes were implanted bilaterally by use of sterotaxic methods in the SNRanterior of each rat, Epileptiform activity was provoked in unilateral cortex by unilateral ,local application of penicillin(200IU) Continuous high-frequency stimulation (HFS, 130Hz) of the SNRanterior was delivered bilaterally or ipsilaterally in experimental rats of different group,thecontrol group received no stimulation .Then, we observed the behavior and EEG of the epileptic rats in various times before or after stimulation. After completion of the experiments,serial sections of brains of rats were cut and Nissl-stained .The rats with electrode tips symmetrically localized in the corresponding SNRanterior were included in our study. Result: 23 rats were included in our study . Both the stimulation of the ipsilateral and bilateral SNRanterior could reduce frequency of epileptiform discharges and inhibit stage 4 and 5 seizure in ten minites after stimulations .The difference of the anticonvulsive effect between bilateral SNR stimulation group and ipsilateral SNR stimulation group was significant after statistic method proceeding. However, with time prolonged,the anticonvulsive effect of the stimulations to SNRanterior declined.Conclusion: Our observation supports the idea that SNR might be inv olved in the control of cortical seizure.High-frequency sti mulation (HFS, 130Hz) of both bilateral and ipsilateral SNR can suppress the penicillin-induced and fully develo ped epilepsy in time -related way .SNR was tolerant to electric stimulation after time was prolonged.
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