| Object: we valued the effect of decompressive surgery on patients of massive brain infarction and the value of defibrase on these patients by reviewing 36 cases hospitalized in 1st teaching hospital of JiLin University from 2000 to 2005. Methods: we divided 36 patients into two groups: surgery group and non-surgery one, so we could observe the patients'general clinical manifestation and the effect of decompressive operation, and then we divided the surgery group into defibrase-used group and control one in order to find out its effect on the patients. Result: (1) The sex ratio is 1.4:1(male:female), and the average age is 52.4-year old, and the level of plasma fibrogen is much higher in the brain thrombus patients than others(P<0.05); (2) GCS in post-operation patients is obviously improved(P<0.001), and the death rate in early-surgery(less than 12 hours after attack) is differentially lower than that in later-surgery and non-surgery(P<0.05), and there is no difference between later-surgery and non-surgery. (3) Defibrase can lower the level of plasma fibrogen. (4) Defibrase can shorten the revival time and better the neurological function, while there is no change in survivor rate and complication. Conclusion: The attack age become smaller and brain thrombus patients become more; the survival rate of early-surgery is obviously higher than later-surgery, and it seems that later surgery has no too much good; defibrase can...
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