The Effect Of LDR On Immune Function Of Patients With Malignant Tumor

Malignant tumor is the disease, which threaten the people health and hadvery high death rate. The immune monitor system has very important functionon the genesis, development and prognosis of the tumors. Many factors leadingto the tumor suppress the immune function and accelerate the genesis anddevelopment of the tumors, so it is the important step to promote the immunefunction. The most methods to promote the human immune function are usingregulators.Luckey TD presented the theory of LDR stimulation effect or hormesis in1982, and oppugned the hypothesis that there is no threshold in the radiationleading to cancer. So it had accelerated the study of low lever radiation. Theacademes all over the world have done a lot of work which radiation inducedgenetic adaptive reaction of the cells, the enhancement of the immune functionand the controlment of the growth and metastasis of the tumor in rencent 20years. They have enriched the theory of LDR stimulation effect or hormesis.The theory of LDR stimulation effect or hormesis includes cellular andorganismal adaptive reaction, enhancement of the immune function and theweaker effection of leading to cancer. LDR can improve the reaction oflymphocyte, boost the formation of antibody enhance the cell-toxicity effection,so the immune function of organism is enhanced. LDR can be appliedextensively in clinical work in order to enhance the immune function ofmalignant tumor patients.United nations scientific committee on the effeces of automic radiation(UNSCEAR) has published reports from the most recent 1986. For Low DoseRadiation (LDR), its dose is less than either 20 cGy of low-LET radiation or 5cGy of high-LET radiation, and dose rate is less than 0.005 cGy/min. But inmajority of experiments it is difficult to achieve so low dose rates, we defineLDR as doses less than 20 cGy of low-LET radiation. We firstly imitated the low dose irradiation through the equivalentsimulation model of body organisma, measured if every layer's doses of thesensitive organs and the equivalent simulation model of body organisma indistance 4 m from Co source is the security range, and present us experiment 60evidences for next clinical experiment. On the security dose basis, we defined malignant tumor case that givenregular radiation therapy and low dose half body irradiation as experimentgroups and only regular radiation therapy as control groups. 1.25 M eVmonoenergy γ-rays low dose half body radiation was given two times everyweek, 10 cGy every time, the whole dose is 100 cGy. Measuring the immunecell surface molecule of peripheral blood of experiment groups and controlgroups patients before RT, midst RT and after RT, we got the message aboutmalignant tumor patients immune function using the means of experimentgroups comparison by itself and with control groups, approached low doseradiation affected malignant tumor patients immune function. We collected twogroups patients last time WBC results prior to discharge and WBC resultspost-discharge, compared WBC breakdown rates, rechecked and followed up byphone on two groups patients 3 ,6 months after radiation-therapy, and knew thesituation of radiation-therapy reaction, recidivism, diversion and death, andpresented experiment evidences for next clinical treatment. The results of measuring immune index indicated:...