Association Of T393C Polymorphism Of GNAS1 Gene And Essential Hypertension

Objectives: To analyz the relationship between T393C polymorphism of GNAS1(guanine nucleotide-binding protein, α-stimulating activity polypeptide 1) gene and essential hypertension(EH), and to make clear whether T393C polymorphism is a risk factor for EH in Chinese.Methods: Two hundred forty six subjects with EH and two hundred twenty two subjects without EH were included in the present study. T393C polymorphism of GNAS 1 was determinded by polymerase chain reaction with restriction fragment length polymorphism.Results: In the present study, 198 subjects(42.31%) were homozygous for the T allele(TT), 215(45.94%) were heterozygous(TC) and 55(11.75%) were homozygous for the C allele(CC). The frenquency of T allele wase 611(65.28%) and the frenquency of C allele was 325(34.72%). The frequencies of genotype in both EH group and control group were in Hardy-Weinberge equilibrium(P=0.998 and P=0.881, respectively). (1) The difference of genotype frequency and allele frequency between two groups was not significant. (2) In the analysis of interactions of T393C polymorphism and other risk factors, this polymorphism were eliminated from the corresponding logistic regression models assuming additive, dominant, and recessive mode of inheritance. (3) In the assuming modes of inheritance, the difference of genotype frequencies were not significant between two groups. (4) There was no effect of interactions of T393C polymorphism and smoking status or drinking status on pathogenesis of EH. (5)...