Association Of ACE2 Gene Polymorphism With The Essential Hypertension And Arteria Carotis IMT

Objective:To investigate the relationship of ACE2 gene polymorphism with EH susceptibility and IMT of carotid in Hunan Han population.Methods:204 hypertension patients and 211 controls were recruited in this trail. Height, weight,blood pressure,fasting blood glucose, triglyceride,cholesterol,high density lipoprotein cholesterol,low density lipoprotein cholesterol,liver function and renal function were tested. The distribution of ACE2 gene A9570G polymorphism were analyzed by PCR-RFLP in all participants.The carotid arteries were performed with ultrsonography in 96 patients.χ2method was performed to evaluate association of genotype with essential hypertension. Logistic regression was performed to evaluate whether the different genotypes become the risk factor of essential hypertension and IMT.1. In male, Genotype frequencies for ACE2 gene A9570G G and A genotypes were 59% and 41% in hypertension group respectively,44% and 56% in controls.There was significant difference of genotype distribution between the cases and controls (χ2=4.907, P=0.027)2. In female, genotype frequencies for ACE2 gene A9570G AA,AG and GG genotypes were 22%,37% and 41% in hypertension group respectively,22%,44% and 34% in controls. There was no significant difference of genotype distribution between the cases and controls (χ2 =1.347, P=0.510).Allele frequencies of ACE2 gene has no significant difference between the cases and controls neither (χ2=0.644, P=0.422).3.When adjusted by risk factors including age, BMI, WHR, FBG, triglyeride, cholesterol, high density lipoprotein and low density lipoprotein, smoking, taking alcohol, EH family hostory, using logistic regression method analysis founded that there was relationship between ACE2 A9570G polymorphism and EH male group (P=0.042) but not in female group.4.The carotid artery IMT had no significant different bewteen different alleles frequence and gene types both in male and female patient(χ2=0.009,P=0.923 andχ2=0.131, P=0.718).l.The ACE2 gene A9570G polymorphism is associated with hypertension in male.G alleles may be the susceptibility gene of hypertension in male.2.The ACE2 gene A9570G polymorphism are not associated with hypertension among three genetypes in female.3.The ACE2 gene A9570G polymorphism is not associated with the carotid artery IMT in different alleles frequence nor genetypes both in male and female.