Study On The Relationship Between Chronic Prostatitis And Vasectomy

The study was divided into two steps. First , we describe the relationship between vasectomy and chronic prostatitis via epidemiologic survey. Then , by clinic examination , we studied the influence and significance of vasectomy on the concentration of testosterone and estradiol in expressed prostatic secretion.THE FIRST STEP:A CROSS-SECTIONAL STUDY ON THE RELATIONSHIP BETWEEN CHRONIC PROSTATITIS AND VASECTOMYObjectives: To determine the long term influence of vasectomy on prostate, investigation was carried out on the relationship between chroni c prostatitis and vasectomy. Materials and methods: We taked a cluster sampling survey in order to make a prevalence study in a community-based population. The survey included NIH-CPSI, sex, age, work and contraception of male workers 25~55 years old. The questionnaires were completed by objects themselves. CP diagnosis was made in accordance with NIH-CPSI≥ 4. The prevalence of CP in the vasectomized groups and non-vasectomized ones were compared.Results : We obtained 1638 samples(189 CP cases , 238 men vasectomized). The prevalence of CP in the vasectomized individuals(19. 75%)was significantly higher than in non-vasectomized ones' (10. 14 %) (P<0. 01). The odds ratio(OR), which confidence interval was from 1.53 to 3. 11, was 2. 18 of this exposure. Conclusions: The prevalence of CP is related to vasectomy.THE SECOND STEP: THE I NFLUENCE AND SI GN IFI CANCE OF VASECTOMY ON THE CONCENTRATION OF SEX HORMONE IN EXPRESSED PROSTATICSECRETIONPurpose: To discuss the influence and significance of vasectomy of the testosterone and estradiol content in expressed prostatic secretion.Materials and methods: Divided the inquiry results of the first step into four groups: vasectomy group without CP^ vasectomy group with CP^ non-vasectomy group without CP> non-vasectomy group with CP. We draw out some survey objects randomly in each group, B ultrasound examined the genital system of each object, collect urine and EPS respectively for Meares-Stamey Test method to germi culture, and collect serum sample at the same time. EPS and serum was stored at - 20 °C. Genitourinary system examination (included rectal touch) was made by a urinary surgeon after training. We divided objects into CP/CPPS groups and controls in the same standard respectively. The actual group result is as follows:? vasectomy group without CP/CPPS: 28 samples, mean age 40. 68 + 5. 60; (2) vasectomy group with CP/CPPS: 21 samples, mean age 39.37 + 6.90; (3) non-vasectomy group without CP CP/CPPS: 29 samples, mean age 39. 31 + 6. 05; (4) non-vasectomy group with CP/CPPS: 28 samples, mean age 39. 14 + 5. 47. There is no statistical significance of the ages of each group(P > 0.05). We measure the concentration of testosterone and estradiol in the EPS and serum of each group with RIA, and deal with the result statistically via two-sample f-testfor independent samples. Then we make analysis of correlation concerning the ratio of the CPSI score of survey object with CP/CPPS and the measured concentration of testosterone and estradiol in EPS. When P<0. 05, it is indicated that there exists a distinct difference. All the datum were processed with the statistical software package SPSS12. 0.Result: The concentration of testosterone and estradiol in the EPS of each group is as follows : CD vasectomy group without CP/CPPS : ET, 14. 74 ±3. 33 nmol/L, EE, 59. 79 ± 14. 47 pmol/L ?, (2) vasectomy group with CP/CPPS: EL 12. 63± 4. 32 nmol/L, EE, 61. 70± 14. 33 pmol/L: (3) non-vasectomy group without CP/CPPS: ET:, 24. 23±5. 67 nmol/L, EE, 65. 33± 16. 56 pmol/L: ? non-vasectomy group with CP/CPPS: ET, 22.02 ± 4. 14 nmol/L, EE, 67.16i13. 40 pmol/L. The concentration of testosterone and estradiol in the serum of each group is as follows: CD vasectomy group without CP/CPPS: ST, 5. 76± 1.34nmol/L, SE.61. 70 ± 19. 48 pmol/L: (g) vasectomy group with CP/CPPS: ST2 5. 69±1.82nmol/L, SE2 64. 60± 18. 82 pmol/L: ? non-vasectomy group without CP/CPPS: ST:1 5. 95+1. 77 nmol/L, SE:) 62. 03± 13. 22 pmol/L: @ non-vasectomy group with CP/CPPS: ST, 5. 80± 1. 91 nmol/L, SE, 65. 28± 14. 38 pmol/L. There is no statistical significance of the difference between EE, SE and ST of each group(P>0. 05). ET of vasectomied groups is lower than non-vasectomied groups (P<0. 05). the ET/EE ratio in vasectomied groups is lower than control groups obviously (P<0. 05). the ET/EE ratio of CP/CPPS groups is lower than control groups. The concentration of testosterone and estradiol and their ratio in the serum have no statistical significance. The ET/EE ratio and the CPSI score of objects with CP/CPPS appear negative correlation, R=-0. 39, (P<0. 05).Conclusions: CD Vasectomy has no influence on the concentration of testosterone and estradiol in serum; ?The ratios of the concentration of testosterone to the concentration of estradiol in EPS (T/E) with CP/CPPS are all lower than control groups. The ET/EE ratio and the CPSI score ofobjects with CP/CPPS appear negative correlation; ?Variation of the concentration of testosterone and estradiol in EPS after vasectomy maybe cause unbalance of regional sex hormone, and then lead to prostatitisprevalence rate increase.