The Comparative Research Of Craniofacial Structural Characteristic Of Syndromic And Nonsyndromic Patients With Cleft Palate

Cleft lip and palate (CLP) is a common craniofacial malformation, which consists of two third of all craniofacial malformations. Schutte and Murray divided CLP into nonsyndromic and syndromic types genetically, the former is isolated CLP (without other malformations) , the latter is usually combined with other malformations. Now, there are over 300 syndromes with CLP have been reported, including dominant , recessive hereditary syndromes and X-link syndromes, about half of CLPs combines with other malformations, including central nervous svstem, cardiovascular system, skeletal system, genital system and eye. Now, there are a lot of reference about the morphological and genetical research of nonsyndromic CLP including craniofacial growth, and some conclusions have been accepted by most researchers. However, because of the lowest incidence and great expressive differences of some symptoms, there are few reports about syndromic CLP, even no reference about the comparative research of craniofacial growth of two types.This research selects syndromic and nonsyndromic CP patients in mixed dentition, describe and compare the differences in craniofacial growth of two groups with lateral cephalometric films, we want to discover the characterstics of craniofacial growth of syndromic CP and corelationship between CLP and othercraniofacial malformations, and find the best opportunity to cure the two syndromes.Select 56 CP patients, from 6 to 14 years old , include incomplete CP male 10, female 10, complete CP male 10, female 10, Treacher Collins syndrome 8, average 8. 3 years old, Pierre Robin syndrome 8, average 9. 3 years old. Assign all patients to take lateral cephalometric films, scan films and localize points and analyze with WinCeph7. 0 by the same doctor , analyse the final data with SPSS12. 0, calculate the means and standard errors and compare the means of two samples with T-test.Results shows that: (l)There are obvious differences in SNB, ANB, it tell us that more anterior-posterior hypoplasia of mandibular bone and vertical height of mandibular posterior part, and two syndromes are accompanied with an anterior-infre rotation, slight differences exist between two groups in MP-Shk Yaxis> NBa-PtG^ ANS-Me, Pog-Go, Cd-Go. S-Go.(2)There is big difference between Pierre Robins and incomplete CPs in PP-FH, however, slight increases have been found in Treacher Collins patients, it tells us that there exist an anterior-infre rotation of maxillary bone in two syndromes, the possible reason is that hypoplasia of base of skull, and slight increase in A-Ptmu S-Ptm tells us more anterior-posterior hypoplasia of maxillary bone in two syndromes than isolated CPs.(3)No obvious differences exist in S-Go/N-Me^ ANS-Me/N-Me, show that there are no big differences on height proportion of face. (4)There are no obvious divitations in the results of complete and incomplete CPs, and the more severe cleft the more malformations. At last, we conclude that there is no obvious corelationship between CP and other craniofacial malformation, CP is a kind of isolated malformation, which can appear with other craniofacial malformations.