Hepatoprotective Effect Of Eleutherococcus Senticosus On Fulminant Hepatic Failure Induced By D-galactosamine And Lipopolysaccharide In Mice

OBJECTIVE: To study the protective effect of Eleutherococcus seniicosus on fulminant hepatic failure in mice. METHODS: fulminant hepatic failure injury-models induced by D-galactosamine(D-GalN) /Lipopolysaccharid(LPS) in mice, and the levels of serum enzyme ALT, AST and TNF-α : the NF-KB activities and DNA damage in liver; the effects of survival on acute liver injury with pretreatment Eleutherococcus senticosus were observed. RESULTS: The oral administration of the water extract and the ethanol-insoluble part of the water extract significantly reduced the levels of serum enzyme ALT, AST and TNF-α Activities, and significantly suppressed NF-KB activities and DNA damage on mice liver. On the other hand, the water extract and the ethanol-insoluble part of the water extract can increased the survival on mice fulminant hepatic failure injury. CONCLUSION: From the results of the present study, we revealed for the first time that the ethanol-insoluble part of the water extract from E. senticosus had an in vivo effect on both apoptosis and necrosis of hepatocytes in fulminant hepatic failure induced by GalN/LPS.