Research Of The Therapeutic Effect Of Low Molecular Weight Heparin On Rats With Acute Respiratory Distress Syndrome

OBTECTIVE To investigate the therapeutic effect of a small dose of low molecular weight heparin on rats acute respiratory distress syndrome. METHODS 30 rats were divided into 3 group:control group, oleic acide group and heparin-treated group. The changes of PaO₂ and PaCO₂ were determined at different period after injection and the changes of water contant, coefficient, pathologic and malondialdehyde contand of lungs were examined at 2 hours after injection. RESULT Decrease of PaO₂ and increase of PaCO₂ in heparin-treated group were slight compared with those in oleic acide group, P<0.01-0.05. Water contant and coefficient of lungs in oleic acide group and heparin-treated group were higher compared with those in control group, P<0.01.Coefficient of lungs in heparin-treated group were lowwer compared with those in oleic acide group, P<0.01. In oleic acide group, alveolar wall showed congestion, edema, necrosis, infiltration of WBC, hemorrhage and edema of alveolar cavity formation of hyaline membrane, while in heparin-treated group, the changes ofalveolar wall and intraalveoli were slight without formation of hyaline membrane. Malondialdehyde contand of lungs in oleic acide group and heparin-treated group were higher compared with those in control group, KO. 01, and malondialdehyde contand of lungs in heparin-treated group were lowwer compared with those in oleic acide group, R0.01. DISCUSSION The low molecular weight heparin play an improtant therapeutic effect on rats with acute respiratory distress syndrome.