Effect Of Glycosides Of Cistanche On Learning And Memory In Alzheimer's Disease Mice And Its Mechanism

Objective: To observe the effect of cistanche glycosides(GCs) on a model of Alzheimer's disease (AD) in mice and its mechmism. Methods: The AD pathological model was made by intracranial lesions with mini-injection of quinolinic acid.The learning and memory of mice were observed by one time training passive avoidance step-down and Y-maze spatial location task;the acivities of SOD, GSH-Px and TChE, the content of MDA in mice brain were detectced by kits; the apoptosis of bain cells were detected by using TUNEL method and telescope; the content of calcium in AD mice brain was detected by electronic microscope. Result: GCs was shown to improve learning and memory deficiency in mice with brain lesions induced by qunolinic acid.To increase activities of SOD, GSH-Px; to reduce activities of TChE and contents of MDA in mice brain; to decrease apoptosis rate in mice brain cells significantly and to reduce the concertration of calcium in mice brain .Conclusion: The protective effects of GCs on a model of AD in mice may be involved in scavenging free radicals,antioxidation,reducing the contents of calcium and inhibition of apoptosis rate in mice brain cells induced by quinolinic acid.