Expression Of Cyclooxygenase-2 And Its Relationship With Neovascularization And Tumor Cell Proliferation In Cervical Carcinoma

Objective To study the expression of COX-2,CD34 and Ki67 in the cervical carcinoma and to evaluate the relationship between the expression of COX-2 and clinical pathological character of patients and neovascularization and tumor cell proliferation in cervical carcinoma,then to explore the mechanism of carcinogenesis of cervical carcinoma.Methods The expression of COX-2 ,microvascular density (MVD)labelled by CD34 protein and proliferation indexes of cancer cells labelled by Ki67 protein in 41 cases of cervical carcinomas and 10 cases of normal cervical epithelia was examined by immunohistochemistry S-P method. The result was observed by light microscope . Differences were analyzed by t test and x~2 testResults (1) The positive rate of COX-2 was 53.66% in cervical carcinomas, which was significantly higher than that in normal cervical epithelia (P<0.01) .The average levels of MVD and Ki67 were separately 41.53 + 10.91 and (66.37 + 9.71) %,as well as 15.85± 4.12 and (18.38 + 4.07) % in the normal cervical epithelia .There was significantly statistical difference between them (P<0.01) .(2)Overexpression of COX-2 in cervical carcinomas was related to lymph node metastasis and depth of invasion,but had no relation to age,FIGO staging,histopathological type and differentiation degree(P>0.05).(3)The MVD and Ki67 indexes were significantly higher in the COX-2-positive rumors than those in the negative ones (P<0.05)Conclusions The expression of COX-2 may play an important role in carcinogenesis and proliferation.Detection of COX-2 protein may be valuable to further understand the biological behavior of cervical carcinoma...