Expression Of Cyclooxygenase-2 Angiogenesis And Tumor Cell Proliferation In Endometrial Carcinoma And Its Relationships

Objective: To study the expression and clinical significance of COX-2, Microvascular density(MVD) and tumor cell proliferation in endometrial carcinoma and its relationships.Methods: Using immunohistochemistry test (S-P methods) , We examined the expression of COX-2, MVD labeled by CD34 protein and proliferation indexes of cancer cells by Ki-67 protein in 60 cases of endometrial carcinoma , 20 cases of endometrial precancerous lesions and 20 cases of normal endometrium.Results: (1)In endometrial carcinoma tissues , the positive rates of COX-2 protein expression, MVD and Ki-67 were significantly higher than that of uterus atypical hyperplasial endometrium and normal endometrium tissues (P<0.001). (2)The expression of COX-2 protein correlated with histological grade (X~2 =6.668 , P<0.05) and pathological type (X~2 = 4.634 ,P<0.05) , but not with muscles invasion (X~2 =3.553 , P=0.0559>0.05), clinical stage (X~2=1.952 , P>0.05) and lymph node metastasis (Fisher' Exact test, P=0.464>0.05)). In endometrial carcinoma , with the histologic grade increased , the positive rate...