Effects Of Simvastatin On Myocardial Fibrosis And Connective Tissue Growth Facror In Renovascular Hypertensive Rats

Objective To investigate the effect of simvastatin on myocardial fibrosis and connective tissue growth factor(CTGF) in renovascular hypertensive rats.Methods The following groups of 24 Wistar rats were studied: Sham group rats, RH rats and RH rats treated with simvastatin (5mg.Kg^-1.d^-1.Systolic blood pressure (SBP) was measured.,collagen concentration (Coll) in terms of hydroxyproline concentration using Bergman method was also detected . VanGieson and immunohistochemistry staining ( SP method) combined with computed morphometty were used to evaluate the total collagen volume fraction (t-CVF), CTGF expression in left ventricular tissue.Results Compared with sham group, The SBP, t-CVF, Coll and CTGF expression increased markedly in RH group (P<0.01). Compared with the RH group, The SBP, t-CVF, Coll and CTGF expression significantly decreased in RH rats treated with simvastatin (P<0.05).Conclusion Simvastatin could inhibit the development of myocardial fibrosis in renovascular hypertensive rats ,Which was probably related to the decrease expression of cardiac CTGF.