The Expression Of Atorvastatin On Myocardial Fibrosis And Connective Tissue Growth Factor In Rats With Renovascular Hypertension

Objectiave To investigate the effect of atorvastatin on myocardial fibrosis and connective tissue growth factor(CTGF) in renovascular hypertensive rats.Methods Twenty-four Wistar rats were divided into 3 groups(n=8 in each group): Sham group, renal hypertension (RH) group and atorvastatin group (RH rat were gavaged with atorvastatin 50mg/Kg/d). Systolic blood pressure (SBP) was measured,collagen concentration (hydroxyproline concentration) was also detected. VanGrieson, immunohistochemistry staining(PV method) and computed morphometry were used to evaluate the total collagen volume fraction (t-CVF),CTGF expression in left ventricular tissue.Results Compared with sham group, SBP,t-CVF,Coll and CTGF expression increased significantly in RH group(P<0.01). Compared with RH group, t-CVF, collagen concentration and CTGF expression decreased in atorvastatin group(P<0.05).Conclusion Simvastatin could inhibit the development of myocardial fibrosis in renovascular hypertensive rats ,which was probably related to the decrease expression of cardiac CTGF .