The Modeling And Experimental Study Of The Dynamic Hyperthermia Induced Blood Flow Change

Thermal therapy is a medical invention which use high or low temperatures to produce a desirable therapeutic outcome and its effectivity is correlated with the accumulation of heat in the object tissue. Blood perfusion is one of the most important parameters in the determination of heat accumulation. Higher blood perfusion takes more heat away from the heated location hence accelerate the distribution of heat in tissue. Lower blood perfusion conduces to the deposition of heat in tissue and causes the thermal damage easily. The influence of the blood perfusion must be considered in the study of thermal dose. Particularly, both the rise of temperature and the thermal damage may cause the change of blood perfusion during in thermal therapy, meanwhile the quantified describe of the change was less seen. Considering this, we developed the related theoretic and experimental study on the dynamic thermal induced blood perfusion change. The content is as follows: A theoretic model was built up firstly to describe the dynamic thermal induced blood perfusion change based on the tissue's thermal damage theory and with the consideration of the experimental results about the studies of thermal induced blood perfusion change. Then the local mesentery blood perfusion changes of normal rats and rats with tumor during thermal therapy (41oC-45oC) were monitored by laser speckle imaging technique and the results proved that the LSI technique was useful for the microcirculation study. Comparison between the experimental data and the theoretical model showed that the model can describe the thermal induced blood perfusion change well. This model is helpful for developing the study of thermal dose in thermal therapy.