| Objective: To evaluate the efficiency of transcatheter closure of arial septal defect (ASD) with domestic-made occluder device. Methods: There were 357 patients with ASD accepted interventional therapy with domestic-made occluder devices between 2000 and 2005 in our department. They were assessed with electrocardiogram (ECG) and transtho-racic echocardiography (TTE) before the procedure and at follow-up of 1 week, six month, 1 year, 2 year, 3 year and more longer. Results: â‘ The success rate of the procedure was 97.5%. The complications mainly occurred in the early stage. During the follow-up, no serious complication was found. â‘¡After transcatheter closure, the preload of right heart significantly decreased, while the volume and diameter of left ventricle increased and left ventricular systolic function improved . During the long-term follow-up, the volume of right atrium and right ventricle was decreased, left ventricular end-diastolic diameter (LVDd) and left ventricular stroke volume (LVSV) continued to increase. The cardiac morphology and function improved further. â‘¢ Thirty-eight patients were associated with multifenestrated ASDs or complex malformations. Except one patient with two ASDs, all patients completed the procedure with a successful rate of 97.4%. Conclusion: The use of domestic-made occlucder device in the treatment of ASDs has a wide application range, high success rate and safe and reliable effect as well without significant complications.
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