Risk Factors For Migraine Without Aura

Migraine accounts for about 37% of all cases of headache which is one of the chief complains that doctors often met. WHO indicated, migraine, hemiplegy, psychologic disorder and dementia have become the most severe chronic functional disorder. As a common functional disease, its potential risk factors are still not well known by now. Objective: To identify risk factors for migraine without aura. Methods: A hospital-based 1:2 pair-matched case-control study was conducted at the General Hospital of Tianjin Medical University, the Second Teaching Hospital of Tianjin University of Traditional Chinese Medicine and the Hospital of Jinghai County during November 2004 to March 2006.Cases were defined as Migraine without Aura, and controls were other patients without headache-related diseases. Each of the cases was matched with two controls, according to nation, age and sex. Then 64 pairs of subjects were obtained. Some information ofthese subjects were obtained about demographic history of diseases, family history of diseases, lifestyle and behavior style variables by questionnaire. Some variables were measured including height, weight, systolic blood pressure(SBP),diastolic blood pressure(DBP). Conditional logistic regression, multivariate logistic regression, principal component analysis, factor analysis and cluster analysis were used to analyze the risk factors and the potential interactions for some risk factors.Results: Results from univariate conditional logistic regression analysis showed that the occurence risk in manual workers was lower than that in mental workers, OR(odds ratio)=0.1800(95%CI:0.0820~0.3960);higher BMI increased the occurrence risk of MO,OR=4.1770(95%CI:2.1470~ 8.8190);family history of migraine and cerebrovascular diseases(high blood pressure > cerebral hemorrhage > infarct) increased the occurrence risk of MO,OR=6.5000(95%CI:2.1190—19.9350), OR=4.3570(95%CI: 2.1470—8.8420);but MO was statistically unrelated to family history of other diseases. Good quality of sleep decreased the occurrence risk ofMO, OR=0.4110(95%CI:0.2560—0.6610).Tea drinking > sweetmeat and some food which contain nitrite(fumigated, bloated and pickled vegetable ,etc) increased the occurrence risk of MO,OR=1.5880( 95%CI: 1.0390—2.4280). OR=6.4880(95%CI:2.6510—15.8740), OR =2.4350 (95% CI:1.2410—4.7780). Those who had sentiment experience invariably and bad contact in work or living increased the occurrence risk of MO, OR = 12.6910(95%CI:4.435— 36.3180), OR=6.6670(95%CI: 1.8350—24.2240), but MO wasn't associated with diet habits > drinking .somking, physical exercises?coffee drinking, vasodilator drugs and fatal unlucky affair in living. The multivariate logistic regression analysis found that higher BMI OR =5.2260 (95%CI: 1.350—20.2290)and sentiment experience invariably OR=9.8970 (95%CI:2.0800—47.0910)were generally associated with increased risk of MO;while manual workers OR=0.1430 (95% CI: 0.0340~0.6010)and good quality of sleep OR=0.2950 (95%CI: 0.1240—0.7010)had been shown to decrease the occurrence risk of MO. The results of interaction analysis included that:(l)Two-ways interactionbetween occupation and quality of sleep were found and those who had exposed to both manual work and good quality of sleep had significantly lower risk than those without these two exposures OR=0.1080 (95% CI=0.0460'~~0.2580).(2)Occupation and sentiment experience invariably were found to have an interaction. The risk of MO for those who are manual workers without sentiment experience invariably were lower than those who are mental workers with sentiment experience Invariably OR=0.0940(95%CI=0.0370~0.2400). (3)Quality of sleep and sentiment experience invariably were found to have an interaction. The risk of MO for those who had bad quality of sleep and sentiment experience invariably were higher than those who had neither bad quality of sleep nor sentiment experience invariably OR=24.5290 (95% CI=3.1990—188.0930).