Comparative Study Between Coronary Artery Bypass Grafting With And Without Cardiopulmonary Bypass For The Systemic Inflammatory Responses And Early Clinical Outcome

[Objective] To Compare the systemic inflammatory responses and early clinical outcomes between coronary artery bypass grafting with and without cardiopulmonary bypass. [Method]20 patients wererandomly divided into two groups: Off-pump coronary artery bypass grafting (OPCAB, n=10) and conventional coronary artery bypass grafting (CCABG, n=10), There were no statistical differences in age, gender, weight, heart function and numbers of the pathological coronary artery before operation. We drew blood from the central vein at 6 time points (the induction of anesthesia,lh,3h,6h and 24h after the heparinization VS the induction of anesthesia, 1h,3h,6h and 24h after the clamping of ascending aorta), then detected the concentration of IL-8, CRP and MDA; At the same time, we recorded the operation time, average number of graft, post-operation mechanical ventilation time, utilization of vasoactive medicine, period of intensive care unit stay, post-operative in-hospital length,quantity of drainage and transfusion, incidence of complication et al. [Result] In both groups, theconcentration of IL-8, CRP and MDA in post-operative is significantly higher than that in preoperative; Their global changing tendency is similar, but the level of OPCAB group is lower than that of CCABG group, OPCAB had an advantage of CCABG in aspect to incidence of arrhythmia, post-operative in-hospital length, quantity of drainage and transfusion, utilization of vasoactive medicine, post-operation creatinine, cost of hospitalization, had shorter operation time andpost-operation mechanical ventilation time. [Conclusion] According to the foundational and clinicalstudy, compared with CCABG, OPCAB can effectively relieve the ischemical reperfusion injury and systemic inflammatory response, improve the early clinical outcome.