| With the development of modern life, noise pollution is moreserious now. The harm of noise on human, especially on the children,has already caused the attention of people. Most of the scientists hadstudied the effects of noise on the immune system of body (excludepregnant body), on the embryo intrauterine growth and on the printeffect of some diseases after birth. The studies found that noise couldinhibit the body's immune system. They only measured the generalindexes of fetal weight,body length etal. Few people studied theeffects of noise on the immune system of pregnant body and thematuration of fetal lung .To get a health baby, we did such anexperiment to investigate the effects of noise on the immune systemof pregnant body and the maturation of fetal lung. The pregnant ratswere exposed to the noise. We tested the level of plasmacorticosterone (Cor) of pregnant rats by RIA, the T,B lymphoprolif-erative activity by MTT, the expression of SP-B mRNA of fetal lungby RT-PCR. Results: 1.At pregnant day 7th,14th, the plasma Cor ofthe control,75dB,90dB groups increased in turn. Differences wereconsidered to be no significant (p>0.05) in every two groups. Atpregnant day 19th, the plasma Cor of the 90dB groups was higherthan that in the control and 75dB groups, differences wereconsidered to be significant (p<0.05);the plasma Cor of the 75dBgroups was higher than that in control group, but difference wasconsidered to be no significant (p>0.05). At pregnant day 21st, theplasma Cor of the control,75dB,90dB groups increased in turn.Differences were considered to be highly significant (p<0.01).2. Atpregnant day 7th,14th,19th,21st,the weight gain of pregnant ratsin the control,75dB,90dB groups decreased in turn, differenceswere considered to be no significant (p>0.05) in each two groups. 3.There were the same variety trend between thymus index and spleenindex of pregnant rats. At pregnant day 7th,14th,the thymus (spleen)index of pregnant rats in the control,75dB,90dB groups decreasedin turn, differences were considered to be no significant (p>0.05) ineach two groups. At pregnant day 19th,21st,the thymus (spleen)index of pregnant rats in 90dB group was lower than that of 75dBgroup, the thymus (spleen) index of pregnant rats in 75dB group waslower than that of control group, differences were considered to beno significant (p>0.05);the thymus (spleen) index of pregnant rats in90dB group was lower than that of control group, difference wasconsidered to be significant (p<0.05). 4. At pregnant day 7th,14th,the stimulation index of T lymphocyte (SIT) in pregnant rats of thecontrol,75dB,90dB groups decreased in turn, differences wereconsidered to be no significant (p>0.05) in each two groups. Atpregnant day 19th,the SIT of pregnant rats of 90dB group was lowerthan that of 75dB group, the SIT of pregnant rats of 75dB group waslower than that of control group, differences were considered to beno significant (p>0.05). At pregnant day 21st,the SIT of pregnant ratsof 90dB group was lower than that of 75dB group, difference wasconsidered to be no significant (p>0.05);the SIT of pregnant rats of90dB group was lower than that of control group, difference wasconsidered to be highly significant (p<0.01);the SIT of pregnant ratsof 75dB group was lower than that of control group, difference wasconsidered to be significant (p<0.05). At pregnant day 7th,thestimulation index of B lymphocyte (SIB) in pregnant rats of thecontrol,75dB,90dB groups decreased in turn, differences wereconsidered to be no significant (p>0.05) in each two groups. Atpregnant day 14th,the SIB of pregnant rats of 90dB group was lowerthan that of 75dB group, the SIB of pregnant rats of 75dB group waslower than that of control group, differences were considered to beno significant(p>0.05). At pregnant day 19th,21st,the SIB ofpregnant rats of 90dB group were lower than that of 75dB group,differences were considered to be no significant (p>0.05);the SIB ofpregnant rats of 90dB group were lower than that of control group,differences were considered to be highly significant (p<0.01);theSIB of pregnant rats of 75dB group was lower than that of controlgroup, difference was considered to be significant (p<0.05). 5. Atpregnant day 19th,21st,the baby weights of 90dB group were lowerthan that of 75dB and control group, differences were considered tobe highly significant (p<0.01). At pregnant day 19th,the baby weightof 75dB group was lower than that of control group, difference wasconsidered to be no significant (p>0.05);At pregnant day 21st,thebaby weight of 75dB group was lower than that of control group,difference was considered to be significant (p<0.05). 6. At pregnantday 19th,the expression of SP-B mRNA in fetal lung of 90dB groupwas lower than that of control group, difference was considered to besignificant (p<0.05);the expression of SP-B mRNA in fetal lung of90dB group was lower than that of 75dB group, difference wasconsidered to be no significant (p>0.05). At pregnant day 21st,theexpression of SP-B mRNA in fetal lung of 90dB group was lowerthan that of 75dB group, difference was considered to be significant(p<0.05);the expression of SP-B mRNA in fetal lung of 90dB groupwas lower than that of control group, difference was considered to behighly significant (p<0.01). At pregnant day 19th,21st,the expressionof SP-B mRNA in fetal lung of 75dB group were lower than that ofcontrol group, differences were considered to be no significant(p>0.05). Results: Noise stress could affect the pregnant rats and thefetal. With the increasing of noise intension and time, the level ofplasma Cor was increased. The immune system function of pregnantrats was inhibited. Intrauterine growth retardation was happened, andthe lung of IUGR was immature. There were intension-effect,time-effect relationship between the effects and noise;concentration-effect relationship between the effects and the plasma Cor.
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