| Orientation: paediatric immunity and rheumatic diseaseBronchial asthma is a kind of common chronic inflammatoryrespiratory diseases. The occurrence of asthma has been risingglobally for many years. And it also can't be ignored in our country.Going along with the spread of, the treatment of Bronchial asthma has beenmore standardized, but this disease still influences people's daily lifemore and more. At present there are many kinds of drugs used in Bronchialasthma, in which Glucocorticoid (GC) is the most effective. It controlschronic inflammatory respiratory disease mainly byimmunosuppression and anti-inflammation. During the catabatic time,the sufferer has to suck a little dosage GC, which has the side-effectsafter long-term application, such as on the density of bones and onsuppress to immunity, and it has been reported a lot, the use of GCcombined with β2 receptor agonist can result in dependence andrebound, and the effect of using it for the second time when asthmaoutbreak will abate gradually, Therefore, by deeper and deeper studyof asthma's pathogenesis, more and more drugs have been used inclinic. It was supposed that regulation of Th1/Th2 deviation mightprovide a strategy for therapy of asthma since occurrence of asthma isrelated with Th1/Th2 deviation.GL, which is used as a drug to protect the liver, has already beenapplied in China for thousands of years. Its efficient element-theinjection type of GL has been applied in clinic and taken out favorableresults, Lucubrate has indicated GL's function in immunitativeregulation, so it has been used in many systemic diseases. Theobjective of the research is to search out a drug which is effective,with little side-effect, suit for long-term appliance and cheap. Thedetails are as follow.1,selection of cases: 60 acute asthmatic children were selectedaccording to ill history and physical sign strictly, excluding thesufferer with cordis or lung disease, immunity system disease orinterfere of drug, the sufferers were divided by random sample into 3teams: GC team, GL team and comparison team, and there are 20patients in each team.2,remedy methods: the comparison team was given some regulartreatment such as antibiotics,β2 receptor reviver, etc.;the GC teamwas given Dexaminson besides regular treatment;the GL team wasgiven GL Qdivd for 14 days besides regular treatment. The patients inthe three teams were taken out some blood both before and aftertherapy. Plasma was collected and kept in low temperature for testing.3,Observation target: the symptom is catabatic: gasping,nosewing faning,cyanopathy, etc fade away with after 3 days and theblister sound of lung disappears. Those changes are ordainedeffectively;Those symptoms vanish is ordained effectively;There isstill a little gasp,the blister sound of lung lessens but which doesn'tvanish is ordained inefficacy after 6 days. And we also detected thepatients' T lymphocyte subsets,IFN-γ,IL-4 before and after therapy.The results show that the GC and GL teams are the same witheach other in efficiency, they both preceded the comparison team, andthere is no distinct difference in statistics. So the curative effect are thesame. IFN-γtakes on a distinct rising trend in GL team, GC team,compared with comparison team, takes on a decline trend. Thoseindicated GC can restrain immunity and GL can induce IFN-γ.Compared with comparison team and GL team, IL-4 is morerestrained in GC team, GL team is more restrained than comparisonteam. It is analyzed that inducing IFN-γmay result in IL-4'decline.CD4/CD8get right after therapy, which is valid in statistics, comparedwith GC and comparison team. Results showed that GL can induce theprocreation of IFN-γ, adjust the equipoise between Th1 and Th2, andregulate the deviation of T lymphocyte subsets to make the ratio ofCD4+/CD8+normal. Compared with GL, GC restrains the procreationof CD4,CD8,and have no power to induce IFN-γor regulate theimmunity. It just bates the immunity.Because asthma's outbreak can lead to a decompensation, theacute-care is in dire need to lessen the patient's suffer and the organinjury by the lack of oxygen. Therefore the research samples includemainly low and middle grade patients, not serious ones. From theavailability we may conclude that the GL, which comes to react after3-4 days, takes effect slower than the GC which takes effect at thebeginning of the course of disease. The fat is redistributed on somemembers in GC team: more fat on face than before, shorter sleepingtime, more exciting mood and better appetite. However, patients in GLteam have no such side-effects.According to the cure effects, the mechanism of GL can besummarized as follow: By suppress A2, to bate PG's anabolism, toraise IL1 and then IL2, induce INF-γ;At the same time, IL-12/18 areinduced, can stimulate INF-γ,as INF-γis increasing, it can induceIgE's production directly. It can promote Th1 and surpress Th2,regulating the deviation of Th1/Th2. IL4 is decreased and IgEbecomes less. As a result, the inflammatory respiratory disease and theconvulsion of smooth muscle will be abated.The objective of the research is to search out a drug which ischeap, safe, compliable, and with little side-effect, instead. The resultis just as we have expected. Except for enlarging the content of thestylebook ,extending the using scope, including some special type ofathma, we can also put GL troche into use, and study whether theinhaling time and dosage can decrease.
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