| HIE is the norminal disease in term infants,moderate andserious HIE always due to the death and exhibit permanent nervoussysterm sequela.We are searchring the effect treatment in order todesease and avoid nervous systerm sequela.Up to the present there isstill without consolidate and intact treated methods for HIE . NGF have been found more than 50 years, it is the one ofstudied clearest neurotrophic factors,It is well known aboutit'sequence of amino acid and CDNA and gene position .The way ofraction between NGF and high affinity receptor and low affinityreceptor have been developed studied. The study of the treatment ofNGF is in the phase of foundation and the beginning of clinicalmedical.It is reported that NGF can been used to treat AD and outernervous system disease. It has demonstrated throuth animalnexperiment that NGF can pass through blood brain barrier, becausethe neonatal blood brain barrier haven't developed matured, andbecause of asphyxia, the protection function of BBB will bebreaked,so the BBB of neonate is relactively opened.NGF can passthrouth neonatal BBB, arrived the brain, prodect and deaseseddamaged of brain. Objective of this study is to observe curative effect of NGFtreating on moderate and serious HIE and find the favoratethreatment time, and provide science data for it's clinical application.Step: First, we evaluate concentra tion of CSF-NSE as a marker ofthe severity and effection of treatment of HIE .Then observation theeffection of NGF in HIE. Object of this study is 30 case of postonal24 hour term infants who have been made a diagnosis of moderateand serious HIE,and given a treatment from 2005.1 to 2006.4 in ourhospital. The cases were divided randomly into three groupsaccording inpatient order.10 Cases were given NGF therapy frompostnatal 3 day as treatment group â… , 10 Cases were given NGFtherapy from postnatal 14 day as treatment group â…¡,and other 10cases weren't given NGF therapy as controls. Three groups wereadministrated colligated treatment. the period of NGF treatment is 3months .Method: The change of concentration of CSF-NSE ofpostnatal 3 day,7day have been observed in acute-term, the time ofthe vanish of cerebral edema through ultrasound scan have beenobserved in acute-term too.NBNA at postnatal 14day,28day andCDCC test at postnatal 4month have been observed inrecovery-term.Result indicated: CSF-NSE is the earlier marker ofevaluation of the severity of HIE and the effective of threatment .Theconcentration of CSF-NSE of postnatal 3 day of two groups have nodifference (p>0.05), but the the concentration of postnatal 7 day oftwo groups have marked difference, The concentration of CSF-NSEat postnatal 7 day of NGF therapy decreased evidently whichcompared to control, and had statistically significant differences(p<0.05);The vanish of cerebral edema observed through ultrasoundscan were rapidly than control groups, and had statisticallysignificant differences (p<0.05);NBNA at postnatal 14day,28dayand CDCC test at postnatal 4 month of NGF therapy groupsincreased evidently which compared to control ,and had statisticallysignificant differences (p<0.05). CDCC test at postnatal 4 month ofNGF therapy group â… increased evidently which compared to NGFtherapy group II, had statistically significant differences (p<0.05).We concluded that concentration of CSF-NSE can be as a earlymarker of the severity and effection of treatment of HIE;NGF canlessen the damage of the brain during both acute and recovery term inHIE;The best approprate therapy time is early at postnatal, the moreerrly the more effective;NGF threating HIE, a s an assistantmeasurement, it is safe and effective, it is worth promoting. It willopen up a new way for the effective therapy of HIE patients.
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