| Transcranial magnetic stimulation (TMS), a non-invasive and painless tool, is apotential therapeutic and diagnostic tool in psychiatry. Recently, there are manyresearches about low-frequency repetitive TMS (rTMS) on the therapy of epilepsy.However, the reason why rTMS is useful is still under discussion. Nowadays,electroencephalography (EEG) is said to have nonlinear dynamical characters, butthere are still no researches about whether the nonlinear dynamical characters of EEGchange after low-frequency rTMS. In this work, nonlinear dynamical characters andpower spectral of EEG were compared before and after low-frequency rTMS on rats.First of all, the present work discussed the influence of low-frequency rTMS onhealthy rats. A train of 100, 0.5Hz rTMS was applied on each rat, with the intensityabove motor threshold, while sham stimulations were conducted on rats of controlgroup. EEG before and after stimulation were collected and analyzed. The resultsshowed that correlation dimension and higher frequency parts were decreasedsignificantly after rTMS, while sham stimulation did not cause this effect. This resultsupport that low-frequency rTMS have inhibitory effects on the brain. A train of 500, 0.5Hz rTMS was applied on a group of rats, with the intensityabove motor threshold. After stimulation, PTZ was injected and rats were expected tohave seizures. Compared with the control group, rats after rTMS developed lowerranks of seizures. At the same time, EEG was recorded before and after rTMS. EEG atdifferent seizure status were grouped and analyzed. How correlation dimensionchanged during seizure development was discussed.At last, the use of TMS to test motor evoked potential (MEP) of rats with spinalinjury was discussed. Results showed that latency of MEP could reflect the injurystatus of spinal cord. In this work, independent component analysis was used todecompose MEP from EMG signals. It seems that this method is helpful to analyzeMEP with blurred start.
|
PDF Full Text Request