Establishment And Investigation Of Adverse Reactions Standard Terminology Retrieve Data Bank

OBJECTIVE: To promote the status of information standardization in Adverse Drug Reactions (ADRs) monitoring to establelishe the Adverse Reactions Standard Terminology Retrieve Data Bank( ARSTRDB) and simple inquest and investigate the practicability of the data bank with information from the data bank of ADRs report forms network of Shanghai. And the words of ADRs in Shanghai ADRs reports were analyzed.METHODS: ARSTRDB and simple inquest based on the World Health Organization Adverse Reaction Terms( WHO-ART) contained bynames was established. ADRs reports information in Shanghai reported from 2002 January to 2005 April in the data bank of adverse drug reactions monitoring centre of Shanghai were collected after input those report forms into the data bank of adverse drug reactions monitoring centre of China. Following fields were studied: ADRs generated date;hospital where the ADRs happened;process prescription of ADRs and treatment;disease;report form code;ADRs' degree;hospital type;trade-name of drug;generic name of drug;reporter's vocation;reporter's professional title;record code;name of ADRs. 7747 pieces of ADRs report forms were selected after those complete repeated ones were rejected. The name of ADRs was matched piece by piece with WHO-ART and ARSTRDB respectively and the practicablity of ARSTRDB was inspected according to matche results. The effect of reporters' position and severe degree to the report quality and the classification of involved organ-systems and utilization of terminology was analyzed. RESULTS: 4394 pieces of record (56.72% among the sum of all ADRs reports in this study) of ADRs are coincident with WHO-ART. The reason that discrepancy is that: â‘ "new" adverse reaction name;â‘¡multi-word name ADRs';â‘¢error writing. The quantity of ADRs that reported by doctors is 4228, which is 54.58% of the sum. It is 2699 and 34.84% respectively that reported by pharmacist while it is 820 and 10.58% by others( nurses and workers in medical business and consumers of drugs). The percentage of records reported by doctors shows downtrend with the increase of the words amont in multi-word name ADRs while it shows ascensus trend by pharmacist and there has no significant changes of that reported by others. There are 11082 adverse reaction words in all the ADRs data( multi-word names were split into single word). 1140 words( contain unrepeated vocabulary 461 pieces)matched unsuccessfully without the ARSTRDB while the number is 150 and 111 with it. 395 pieces of vocabulary were involved in the whole names of ADRs which grouped in 29 organ-system classification. 21 terms emerged 8509(77.83%) vices which the frequency of occurrence beyond 100. The average frequency of occurrence of other 374 terms is 6.88. The first 5 terms are: rash;pruritus;anaphylactoid reaction;nausea;vomiting. CONCLUSIONS: Doctors and pharmacists are the major reporter of ADRs and the former grasp terminology better than others but sometimes would use synonym to denominate adverse reactions while the latter do not well in terms prehension and medical phenomenon recapitulation. The quantity of those reported by nurses and workers in medical business and consumers of drugs is small. The usage of adverse reactions terminology and the level of ADRs monitoring is low. The Adverse Reactions Standard Terminology Retrieve Data Bank has practical value- it can promote the status of information standardization in ADRs monitoring and diminish the quantity of report info needed analysis by people and help researchers to investigate data of adverse drug reactions more lightly and efficiently.