Studies On Orally Disintegrating Tablet Of Helicid

Objective To develop Helicid orally disintegrating tablets, and to provide a more convenient, safety and effective medicine. Methods Effervescent was evaluated carefully including its influence on the disintegrating time of blank tablets in vitro and in vivo. The formulation was optimized by central composite design and response surface methodology using disintegrating time as evaluation index. The in vivo behavior of the tablets was evaluated in beagle dogs after administration of orally disintegrating tablets and ordinary tablets in the market. Pharmacokinetic parameters of the two formulations were compared, and the relative bioavailability was calculated. Results The optimized formulation was SMCC 5.4%, PVPP 5.8%, effervescent 12%, and the disintegrating time and hardness of the tablet using above formulation can comply with the request, having a faster dissolving speed compared with ordinary tablets in the market. Conclusion Compared with the common tablets , the orally disintegrating tablets showed quicker dissolution in vitro andfaster absorption and higher peak concentration in vivo.