| OBJECTIVE Senescence relates to human's lifespan and death closely, which is a complex physical process and involves lots of medical fields. About mechanisms of senescence, many theories have been promulgated. Among all the theories of aging, demonstrated by more and more researches, free radical theory is considered as the most believable theory. Free radical theory of aging predicts crucial role for free radicals produced by external factors and pathological disorders in the initiation of aging, which is based on the hypothesis that free radicals react with biological molecules, increase DNA damage, result in bond breakages, accelerate lipid peroxidation on biological membranes, and accumulations of reacting products influence the ability of tissues and organs to carry out critical biological functions. At present, researches and applications of antisenescence supplements are widely recommended in fields of food & health. Based on the free radical theory of aging, current researches have revealed potential antiaging effect of foods with antioxidant properties. Emerged as a novel functional food additive, lycopene (LP) has been of particular interest in recent years. Lycopene, an efficient antioxidant and singlet oxygen quencher, is an acyclic, biologically active carotenoid that gives tomatoes and other fruits and vegetables their red colour. Dietary intakes of lycopene have been shown to be associated with decreased risk of chronic diseases such as cancer and cardiovascular diseases, as well as enhanced immune function in numerous studies. However, very little information is available about the antiaging potential of lycopene. Thus, on the basis of previous investigations, this study was designed to evaluate antisenescence effect of lycopene from two aspects: one was on lifespan...
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