The Role Of HSP90 And ERα And Their Correlation In Carcinogenesis,Progression Of Epithelial Ovarian Tumors

Objective :To investigate the correlation between the expression of HSP90 and ER a in epithelial ovarian tumors and their roles in carcinogenesis , progression and treatment of epithelial ovarian tumors . Methods :6 samples of normal ovarian tissues , 8 samples of benign epithelial ovarian rumors , 6 samples of bordline epithelial ovarian tumors and 24 samples of epithelial ovarian carcinomas were examined for the expression of HSP90 and ER a , and their correlation by S-P immunohistochemistry . Results :1 .Expression of HSP90 in normal ovarian tissues , benign epithelial ovarian tumors , bordline epithelial ovarian rumors and epithelial ovarian carcinomas was different (H_C=16.73,P <0.05) : expression of HSP90 in epithelial ovarian carcinomas was stronger than that in normal tissues , benign or bordline epithelial ovarian tumors respectively(P <0.05);but the expression of HSP90 from normal tissues to bordline epithelial ovarian tumors was not significant difference (P> 0.05) .2.Among clinicopathological parameters of epithelial ovarian carcinomas (age , histological subtype , grade , lymphnode metastasis , ascites , distance metastasis ,FIGO stage and chemotherapy before surgery), HSP90 expression was correlated with age and FIGO stage , HSP90 expression became strong with increase of age and FIGO stage(P <0.05 ) .3.The expression of ERa in four groups was not statistical significance (Hc=6.88, P>0.05) .4. Among clinicopathological parameters of epithelial ovarian carcinomas , expression of ER a in serous adenocarcinoma was stronger than that in mucinous and clear cell adenocarcinoma (P<0.05).5.Expression of HSP90 had direct correlation with the expression of ERa(rs=0.5854,p<0.001). Conclusions :1. Expression of HSP90 in normal ovarian tissues , benign epithelial ovarian tumors > bordline epithelial ovarian tumors was not significant difference;expression of HSP90 in epithelial ovarian carcinomas was remarkably increased . It was suggested that HSP90 could induce carcinogenesis of epithelial ovarian tumors .2. In epithelial ovarian carcinomas , HSP90 expression became strong with increase of age and FIGO stage. HSP90 may contribute the epithelial ovarian carcinomas to aggression.3. From normal ovarian tissues to epithelial ovarian carcinomas, expression of ER a was increased gradually, but was not significant difference .4. Expression of ER a in ovarian serous adenocarcinoma was stronger than that in mucinous and clear cell adenocarcinoma . This finding could indicate that ER a play difference roles in different histological subtype .5. Expression of HSP90 had direct correlation with the expression of ER a . HSP90 may be in coordination with ER a in carcinogenesis -, progression of epithelial ovarian tumors.