| PART â… The Expression of Heparanase in Human Non-small Cell Lung CancerObjectiveTo review the relationship between human heparanase expression and clinical pathology characters of biological factors in human non-small cell lung cancer(NSCLC), and estimate whether it can be a index of invision and metastasis in human NSCLC.Material and methodsThe expression of heparanase was assessed in 66 paraffin-embedded specimens by immunohistochemical staining(S-ABC), the specimens were come from the department of Thoracic Surgery in General Hospital of PLA from January to December in 2000,the 66 specimens contrast to the 15 normal lung tissues,collecting patients' clinical pathology datas and follow up whether patients died of recurrence or metastasis.The relationship between heparanase expression and the clinical pathology factors was analyzed by Chisquare test,Kaplan-Meier and multivariate analysis method.Resultshi the immunoreactive cells, staining was mainly located in cytoplasma and /or membrane.Human heparanase was highly expressed in lung cancer tissues(74.2%, 49/66)while negative in epithelia of normal lung tissues.The expressionof heparanase significantly correlated with TNM stage(P=0.042) and lymphatic metastasis(P=0.005).The patients with positive heparanase expression had a significantly shorter survival rate than those with negative heparanase expression(P:=0.025).While in multivariate analysis, the expression of heparanase could not be considered as one of risks in prognostic factors.ConclusionHeparanase might play an important role in the development, invasion and metastasis of NSCLC. Heparanase may be one of reliable markers for the metastatic activity gained by the NSCLC and could be used clinically in predicting metastatic recurrence of NSCLC. It is indicated that patients with positive heparanase expression would have a greater chance ofmetastasis and a poorer prognosis. However, heparanase expression is not an independent prognostic factor.
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