The Investigation Of Fusion Of ～(131)I-SPECT And CT Images On Detecting Pate And Mediastinal Metastases With Differentiated Thyroid Carcinoma

Objective To compare the value of ¹³¹I-SPECT/ CT imaging and US, CT , ¹³¹I-WBI in detection of head and neck and mediastinal metastases from differentiated thyroid carcinoma.Methods US of pate, CT, ¹³¹I-WBI and ¹³¹I-SPECT/CT images of pate and mediastinum were respectively performed within two weeks to 30 patients with differentiated thyroid carcinoma proved by pathologic diagnosis after operation. Then, retrospective analysis and comparison were carrying out.Results 106 metastatic lesions were proved in 30 patients , ¹³¹I-SPECT/CT imaging found 99 (93.4 %)metastatic lesions, whereas US , CT , and ¹³¹I-WBI found 59 (77.6%), 77 (72.6 %), and 87 (82.1%), respectively. Analysis of different anatomical areas showed that on the head and neck, ¹³¹I-SPECT/CT imaging found 71 (93.4 %)metastatic lesions, whereas US , CT , and ¹³¹I-WBI found 59 (77.6%), 56 (73.7 %), and 63 (82.9%), respectively. while on the mediastinal part, ¹³¹I-SPECT/CT imaging found 71 (93.4 %)metastatic lesions, whereas CT , and ¹³¹I-WBI found 28 (93.3%), 21 (70.0 %), and 24 (80.0%), respectively. The result of ¹³¹I-SPECT/CT was compared with that of US, CT, and ¹³¹I-WBI, The difference was significant (x²=7.65, 16.19, 6.31. P< 0.01, 0.01, 0.05, respectively) .Conclusion ¹³¹I-SPECT/CT fusion imags could improve detection of metastatic lesions of differentiated thyroid carcinoma, and have higher clinical value in the aspect of correct diagnosis of metastatic lesions and evaluating therapeutic efficacy of ¹³¹I.