Diagnostic Values Of VEGF, CRP And CEA In Differentiating Between Tuberculosis And Malignant Pleural

Objective The aim of this study was to explore the clinical validity of vascular endothelial growth factor (VEGF) and c-reactive protein (CRP) and Carcinoem bryonic antigen(CEA) in discriminating between tuberculosis pleuritis(TBP) and malignant pleural effusion (MPE).Methods The tuberculosis pleuritis group is 20,the malignant pleural effusion group is 18, the serum and pleural effusion VEGF were measured by enzyme-linked immunosorbent assay . the serum and pleural effusion CRP were measured by immunoturbidimetric method . the pleural effusion CEA were measured by chemilumnoescence immunoassay.Results 1.VEGF levels in the serum were (1.80±0.06 ng/L) significantly higher in the patients with malignant pleural effusion than (1.50±0.23 ng/L) in the patients with tuberculosis pleural effusion (P <0. 001) . VEGF levels in the pleural effusion were (3.46+0.64 ng/L) significantly higher in the patients with malignant pleural effusion than (2.07± 0.46 ng/L) in the patients with tuberculosis pleural effusion2. Pleural effusion CRP levels were (1.50±0.29 mg/L) significantly higher in patients with tuberculosis pleural effusion than(1.13+0.24 mg/L) in the patients with malignant pleural effusion(P <0. 001) ,serum CRP levels was not different between malignantpleural effusion ( 1.46 + 0.45 mg/L ) and tuberculosis pleuraleffusion(1.60+0.30 mg/L)(P >0.05).3. CEA levels in pleural effusion was significantly different between malignant pleural effusion (1.70+0.97 u g/L) and tuberculosis pleural effusion (0.07 + 0.03 u g/L) (P<0.001)4. The sensitivity, specitivity and accuracy of detecting VEGF , CRP , CEA in pleural effusion were 83.3%, 95.0%, 89.1%. 72.0 %, 90.0 %, 81.5%. 72. 2 %, 100.0 %, 86.8%, respectively, for malignant pleural effusion. The sensitivity, specitivity and accuracy of combinative detecting VEGF and CRP and CEA in pleural effusion were 88.9 % > 95.0 %> 92.1% oConclusion 1. The detection of VEGF, CRP ,CEA has diagnostic values in differentiating between tuberculosis and malignant pleural effusion.2. The combinated detection of VEGF , CRP and CEA has importantly diagnostic values in differentiating between tuberculosis and malignant pleural effusion.