Expression And Clinical Significance Of Souble Vascular Endothelial Cadherin In Patients With Coronary Artery Disease

Objective: We measured the serum level of Soluble VE-cadherin in patients with coronary artery disease, to investigate the relationship between serum Soluble VE-cadherin levels and coronary artery disease.Methods : The levels of serum VE-cadherin were determined by enzyme-1inked immunosorbent assay in 20 acute myocardial infarction (AMl) cases, 22 unstable angina(UA) cases, 19 stable angina (SA) cases and 19 healthy cases as control. The correlation between the plasma VE-cadherin concentration and the Gensini score was also determined as an index of the severity of coronary atherosclerosis.Result: Compared with healthy control subjects (2.36 ± 2.26) ng/ml ,The plasma concentrations of VE-cadherin (ng/ml)in patients with AMI (5.07 ±2.72) ng/ml, UAP (4.73 ±2.50) ng/ml, and SAP (4.13 ±2.47) ng/ml were higher than in the control subjects (.P<0.05), and no difference in the 3 groups with coronary artery disease( P>0.05). The plasma VE-cadherin concentration correlated with the Gensini score (r=0.51 P<0.01) . Multiple regression analysis revealed that the plasma VE-cadherin concentration predicted the Gensini score independently of traditional CAD risk factor.Conclusion : Increased secretion of VE-cadherin from the epicardial arteries is associated with the degree of coronary atherosclerosis, indicating the presence of atherosclerosis rather than disease activity.