The Research Of New ChineseTraditional Medicine YinGuanGanMao Granule

When the bacteria or virus infection are confined to the nasal cavity orthroat,we call them upper respiratory tract infection ,which is one of the mostcommon infectious diseases, the incidence of all ages,sex,occupations andregions, there are lots of people catch cold every year,mostly caused by thevirus (about 90%), Mycoplasma infect account for 4～5%, only 1～2%bacterial infections. The common virus are rhinovirus,Coronaviruses andinfluenza virus, parainfluenza virus, respiratorysyncytialviuspneu and ECHOvirus, C.oxsackieViruses and so on .Substantial clinical practice and preliminary animal experiments confirmthat the mechanisms of traditional medicine are different from those of theWestern medicine in treatmenting influenza, which was not directly destroypathogenic micro-organisms, but more to adjust overall, change pathologicalprocess, to get the therapeutic purpose by promoting organisms to resistthepathogens. Which made the Chinese medicine can both treat of influenza andsignificantly avoid drug resistance and side effects meanwhile. Just as therespiratory infection is concerned, with the wider use of antibiotics andwidespread of organ transplant and bone marrow transplant, Respiratoryinfection has increasingly been extensive attentioned at home and abroad .Theviral respiratory infections especially upper respiratory tract infection in theelderly,children and low immunization groups are may be fatal. because whichhave closely link with the body's Immunization status. Normally only whenimmune function is decrease can we catch the disease .Therefore the CompoundChinese medicines with the double fuctions which can both anti-virus andimprove or adjust immune functions are much more effective than simplyanti-viral medicine such as Ribavirin.Yinguanganmao granule is a compounded medicine which is researched byour laboratory to treat upper respiratory tract infection.floslonicerae ,radixissatidis,rhizoma adryopteris crassirhizomatis,radix scutellariae,herbataraxaci,radix glycyrrhizae are the main composition of it . We can obtain onethousand pellet drugs when we use floslonicerae 400 gram, radixissatidis 450gram, rhizoma adryopteris crassirhizomatis 370 gram, radix scutellariae 370gram, herba taraxaci 269 gram, radix glycyrrhizae 269 gram, and some otherdrug complements.heat up and back flow the floslonicerae with 80% ethanoltwo times ,each 2 hours.the amouts of the ethanol are 8 times of the amounts ofthe medicine .then to felter and recycle until no the taste of ethanol ,then thecondensede liquid to stande by. mixed the Residues of floslonicerae with theother medicine ,boxed them 3 times with water ,each 2 hours,the amount of thewater is 8 times of the amount of the medicines.Condensed them to the relativedensity of about 1.12, then add some ethanol till the content of ethanol is60%,felter and recycle until no the taste of ethanol ,mingle them with thestandby floslonicerae condense liquids and condense them to the relative densityof about 1.30～1.35(80℃),rather dry to dry paste and crush them ,then mixthem with the other drug complement, We make them well distributed andgranulate by use 95% ethanol.In order to control the quality of raw material and the granule, we useTLC to videntify floslonicerae,radix scutellariae,radix glycyrrhizae.and HPLCto determine the contents of Chlorogenic acid . The result show that this methodis feasible repeated stability and the complement don't disturb the determination.It can be used to control the inside quality of the drug.We make the extraction process be more suitable for production in largepharmaceutical factory by using orthogonal intersection experiment. From theresult of pharmacodynamics and narcotics experiment, we could know that thisdrug can be used to treat pharynx inflammation and the curative effect is good,the side-effect is low.The incidence of respiratory tract infections are very high , at present,although there are more varieties listed, but not very clear efficacy, the drugbelonged to Chinese medicine class six drugs . Now in the national drugsupervision bureau proceedings. Successful development of the drug. Will be atremendous economic and social benefits.